Opioids Analgesics Flashcards
What is a pure opioid agonist?
Morphine
What is the Nonopioid Centrally Acting Analgesics?
Tramadol
What is the pure Opioid Antagonist?
Naloxone
What is the MOA for morphine?
Mimics the actions of endogenous opioid peptides
What are the pharmacokinetics for morphine?
IV doses «_space;Oral due to 1st pass effect
What are the serious adverse effects of morphine?
Respiratory distress
Overdose
What are the common adverse effects of morphine?
Constipation
Urinary retention
Nausea
What do you want to check for upon pre-adminstration of morphine?
Respiratory Rate
Mental Status
Blood Pressure
How slow should you inject morphine?
over 4-5 minutes
What is the key education for morphine?
Fall risks
limit hazardous activity due to drowsiness
Increase fluid, fiber, and activity to limit constipation
Cough at regular intervals
What scale do you want to use to assess sedation?
Richmond Agitation and Sedation Scale (RASS)
What is the classic triad for an opioid overdose?
Coma
Respiratory depression
Pinpoint pupils
What is considered the ‘antidote’ for an opioid overdose?
Naloxone (Narcan)
What is the MOA of Tramadol
Blocks uptake of norepinephrine & serotonin
What are the adverse effects of Tramadol?
Sedation Dizziness Headache Dry Mouth Constipation