Calcium Channel Blockers Flashcards
What kind of muscle are Calcium Channel Blockers used for?
Smooth Muscle
What are agents that affect the heart and blood vessels called?
Orphan CCB
What are agents that act mainly on blood vessels called?
Dihydropyridines
What are the two Orphan CCB called?
Verapamil
Diltiazem
What is the Dihydropyridine called?
Nifedipine
What are Orphan CCB used for?
Angine Pectoris
Essential HTN
Cardiac dysrhythmias
What is the MOA of Orphan CCB?
Dilation of peripheral arterioles lower after-load
Decrease HR, AV conduction, force of contraction
What are the adverse effects of CCB?
Constipation Dizziness Facial flushing Edema Worsening Cardiac dysfunction
What is a drug/drug interaction with Orphan CCB?
Digoxin
Beta Blockers
What do you want to assess before administering Orphan CCB’s?
HR
BP
Chest Pain History
What do you want to evaluate after you administer Orphan CCB’s?
Assess for over-shooting
Monitor for increased peripheral edema
What is the use of Nifedipine?
Angina pectoris
Essential HTN
What is the MOA if Nifedipine?
Dilation of peripheral arterioles lower afterload
What are the two different dosing for Nifedipine?
Sustained Release
Immediate Release
What are the adverse effects of Nifedipine?
Dizziness Facial flushing Edema Reflex tachycardia Toxicity
What is a drug interaction for Nifedipine?
Digoxin
What do you assess before administering Nifedipine?
HR
BP
Chest Pain History
Renal and liver function (drug gets metabolized by liver)
What do you want to evaluate after administering Nifedipine?
Severe hypotension and cardiotoxicity
What does the selective dilation of arterioles do?
Decreases afterload
What does the selective dilation of veins do?
Decreases preload
What are the adverse effects related to vasodilation?
Postural hypotension
Reflex tachycardia
Expansion of blood volume
What is the use of Nitroglycerin?
Reduction of frequency and intensity of angina attacks
What is something to know when it comes to dosing of Nitroglycerin?
Continuous use of Nitro can produce tolerance within 24 hours
What are some adverse effects of Nitro?
Headache
Orthostatic hypotension
Reflex tachycardia
What do you want to check in the MAR before administering Nitro?
PDE5 inhibitor