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hema - review > WBC Anomalies > Flashcards

WBC Anomalies Flashcards

1
Q

nuclear remnants of lymphocytes

-thumbprint appearance

A

Smudge cells

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2
Q

nuclear remnants of granulocytic cells

A

Basket cells

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3
Q

lymphocyte with hand-mirror appearance

–protrusion from cytoplasm

A

Hand-mirror lymphocytes

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4
Q

Alius-Grignaschi Anomaly aka.

A

Myeloperoxidase deficiency

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5
Q

low or absent myeloperoxidase enzyme

A

Alius-Grignaschi Anomaly

-normal ang cell morph

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6
Q

seen in IM

A

Hand mirror lymphocytes

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7
Q

tests in Chronic Granulomatous disease

A
  1. Chemiluminescence

2. Nitroblue Tetrazolium Reduction

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8
Q

CGD (+) in NBT reduction appears

A

no color change

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9
Q

Chronic Granulomatous disease affects what cells

A

Nuetrophils

able to engulf BUT NOT ABLE to DIGEST

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10
Q

more commonly affected gender in CGD

A

Boys

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11
Q

what are formed in CGD

A

Granulomas

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12
Q

deficiency in sphingomyelinase

A

Niemann-Pick Disease (NPD)

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13
Q

Cells found in Niemann-Pick disease

A

foam cel (Pick cell)

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14
Q

foam cell/pick cell is what cell?

A

Macrophage

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15
Q

NPD common in

A

Ashkenazi Jews

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16
Q

a defect in catabolic enzyme Beta-glucocerebroside

A

Gaucher disease

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17
Q

Gaucher disease cells appearance

A

crumpled tissue paper, onion skin appearance

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18
Q

pseudogaucher cell

A

myeloproliferative disorders

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19
Q

most common of the lipidoses

A

Gaucher disease

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20
Q

Gaucher disease tests

A
  1. Chitotriosidase

2. PAS

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21
Q

nucleus has greater than or equal to 6 lobes

A

Hypersegmented neutrophils

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22
Q

Hypersegmented neutrophils seen in

A

megaloblastic anemias

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23
Q

rare hereditary condition characterized by normal granulocyte production; nevertheless, there is impaired
release into the blood

A

Myelokathexis

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24
Q

Pelger-huet anomaly aka.

A

True or Congenital PHA

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25
Pince-nez or spectacle form of nucleus
PHA
26
Pseudo pelger huet anomaly aka
Acquired PHA
27
Acquired PHA is seen in
``` acute myeloid leukemia, chronic myeloproliferative neoplasms, and myelodysplastic syndromes (MDS), HIV infection, tuberculosis, Mycoplasma pneumo ```
28
hyposegmentation
1-2 lobes
29
most common genetic disorder of WBC
PHA
30
Neutrophils in TRUE PHA
- show normal granulation | - function normally
31
Lupus Erythematosus cell (LE)
Found in SLE also in connective tissue disorders
32
neutrophil that has ingested the antibody-coated nucleus of another neutrophil or has engulfed the homogenous, globular nuclear mass of a destroyed cel
Lupus Erythematosus cell (LE)
33
Thesaurocyte
Flame cell
34
abnormal plasma cell with intensely eosinophilic or "flaming" cytoplasm
Flame cell/Thesaurocyte
35
flame cells are found in
IgA myeloma
36
considered to be an artifact, found in CLL, "Cloverleaf-like. -normal lymphocyte but NOTECHED nucleus
Rieder cell
37
Morula cell/Mott cell
Grape cell
38
abnormal plasma cell with a cytoplasm | that is completely filled with Russel Bodies
Grape cell
39
found in Multiple myeloma (Plasma cell myeloma)
Grape cell
40
dense azurophilic granulation in all types of leukocyte -looks like toxic granules
Alder-Reilly anomaly
41
mucopolysaccharidoses
Alder-Reilly anomaly
42
Alder-Reilly anomaly
Granulation results from an abnormal | deposition and storage of mucopolysaccharides
43
other names for Alder-Reilly anomaly
1. San filippo syndrome 2. Hurler syndrome 3. Hunter syndrome
44
basic defect in golgi complex
Chediak-Higashi syndrome
45
giant cytoplasmic granules
Chediak-Higashi syndrome
46
Chediak-Higashi syndrome cells
phagocytes (granulocytes, monocytes) | occasional in lymphocytes
47
seen in partial albinism
Chediak-Higashi syndrome
48
Small lymphocytes with little cytoplasmic | projections
Hairy cells
49
test for Hairy cells
TRAP - Tartrate Resistant Acid Phosphatase
50
TRAP result for Hairy cells
(+)
51
what is produced by Hairy cells to be tartrate reistant?
- Isoenzyme 5
52
may be seen in drug sensitivity
Tart cells
53
monocyte that has ingested a whole | lymphocyte or a nucleus
Tart cells
54
-Altered primary granules (present because | of rapid cell maturation)
toxic granulations
55
toxic granulations appear like
Alder-reilly
56
toxic granulation is seen in
severe infections and chemical poisoning (Lead poisoning)
57
linear projections of primary granules (rod-like)
auer rods
58
Auer rods seen in certain types of
AML
59
Abnormal WBC with bundles of Auer rods in its cytoplasm
Faggot cell
60
owl's eyes
Reed-Sternberg cell
61
what cell is a Reed-Sternberg cell
lymphoid cell
62
definitive histiologic characteristic of Hodgkin's disease
Reed-Sternberg cell
63
-Poor neutrophil response to chemotactic | agents
Lazy leukocyte syndrome
64
hyperimmunoglobulinemia E syndrome
Job syndrome
65
characterized by recurrent severe bacterial infections, skeletal abnormalities, and elevated levels of IgE
Job syndrome
66
presence of fat-containing vacuoles in granulocytes and monocyte
Jordan's anomaly
67
Jordan's anomaly is seen in
muscular dystrophy & icthyosis
68
Round or oval blue-staining cytoplasmic inclusions found in neutrophils (arranged in parallel rows and consisting of ribosomal RNA)
Dohle bodies
69
: pregnancy, severe burns, aplastic anemia, scarlet fever and other infectious diseases, and following administration of toxic agents
dohle bodies
70
appear like dohle bodies but with giant platelets | -gray-blue spindle shaped inclusions
May-Hegglin anomaly
71
Dohle bodies vs MHA inclusions are diff. by
size shape PAS Content
72
Dohle bodies vs MHA inclusions: PAS (+)
Dohle bodies
73
Dohle bodies vs MHA inclusions spindle-shaped
MHA inclusion
74
Dohle bodies vs MHA inclusions: larger in size
MHA inclusion
75
Dohle bodies vs MHA inclusions: contents
mRNA: MHA ribosomal RNA : Dohle ("DR")

hema - review (17 decks)

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