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hema - review > WBC Anomalies > Flashcards

WBC Anomalies Flashcards

1
Q

nuclear remnants of lymphocytes

-thumbprint appearance

A

Smudge cells

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2
Q

nuclear remnants of granulocytic cells

A

Basket cells

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3
Q

lymphocyte with hand-mirror appearance

–protrusion from cytoplasm

A

Hand-mirror lymphocytes

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4
Q

Alius-Grignaschi Anomaly aka.

A

Myeloperoxidase deficiency

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5
Q

low or absent myeloperoxidase enzyme

A

Alius-Grignaschi Anomaly

-normal ang cell morph

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6
Q

seen in IM

A

Hand mirror lymphocytes

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7
Q

tests in Chronic Granulomatous disease

A
  1. Chemiluminescence

2. Nitroblue Tetrazolium Reduction

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8
Q

CGD (+) in NBT reduction appears

A

no color change

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9
Q

Chronic Granulomatous disease affects what cells

A

Nuetrophils

able to engulf BUT NOT ABLE to DIGEST

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10
Q

more commonly affected gender in CGD

A

Boys

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11
Q

what are formed in CGD

A

Granulomas

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12
Q

deficiency in sphingomyelinase

A

Niemann-Pick Disease (NPD)

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13
Q

Cells found in Niemann-Pick disease

A

foam cel (Pick cell)

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14
Q

foam cell/pick cell is what cell?

A

Macrophage

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15
Q

NPD common in

A

Ashkenazi Jews

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16
Q

a defect in catabolic enzyme Beta-glucocerebroside

A

Gaucher disease

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17
Q

Gaucher disease cells appearance

A

crumpled tissue paper, onion skin appearance

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18
Q

pseudogaucher cell

A

myeloproliferative disorders

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19
Q

most common of the lipidoses

A

Gaucher disease

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20
Q

Gaucher disease tests

A
  1. Chitotriosidase

2. PAS

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21
Q

nucleus has greater than or equal to 6 lobes

A

Hypersegmented neutrophils

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22
Q

Hypersegmented neutrophils seen in

A

megaloblastic anemias

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23
Q

rare hereditary condition characterized by normal granulocyte production; nevertheless, there is impaired
release into the blood

A

Myelokathexis

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24
Q

Pelger-huet anomaly aka.

A

True or Congenital PHA

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25
Q

Pince-nez or spectacle form of nucleus

A

PHA

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26
Q

Pseudo pelger huet anomaly aka

A

Acquired PHA

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27
Q

Acquired PHA is seen in

A 
acute myeloid
 leukemia, 
chronic myeloproliferative
neoplasms, and myelodysplastic
 syndromes (MDS), HIV infection,
 tuberculosis, Mycoplasma pneumo
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28
Q

hyposegmentation

A

1-2 lobes

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29
Q

most common genetic disorder of WBC

A

PHA

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30
Q

Neutrophils in TRUE PHA

A
  • show normal granulation

- function normally

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31
Q

Lupus Erythematosus cell (LE)

A

Found in SLE also in connective tissue disorders

32
Q

neutrophil that has ingested the
antibody-coated nucleus of another neutrophil
or has engulfed the homogenous, globular
nuclear mass of a destroyed cel

A

Lupus Erythematosus cell (LE)

33
Q

Thesaurocyte

A

Flame cell

34
Q

abnormal plasma cell with intensely eosinophilic or “flaming” cytoplasm

A

Flame cell/Thesaurocyte

35
Q

flame cells are found in

A

IgA myeloma

36
Q

considered to be an artifact,
found in CLL,
“Cloverleaf-like.
-normal lymphocyte but NOTECHED nucleus

A

Rieder cell

37
Q

Morula cell/Mott cell

A

Grape cell

38
Q

abnormal plasma cell with a cytoplasm

that is completely filled with Russel Bodies

A

Grape cell

39
Q

found in Multiple myeloma (Plasma cell myeloma)

A

Grape cell

40
Q

dense azurophilic
granulation in all types of leukocyte
-looks like toxic granules

A

Alder-Reilly anomaly

41
Q

mucopolysaccharidoses

A

Alder-Reilly anomaly

42
Q

Alder-Reilly anomaly

A

Granulation results from an abnormal

deposition and storage of mucopolysaccharides

43
Q

other names for Alder-Reilly anomaly

A
  1. San filippo syndrome
  2. Hurler syndrome
  3. Hunter syndrome
44
Q

basic defect in golgi complex

A

Chediak-Higashi syndrome

45
Q

giant cytoplasmic granules

A

Chediak-Higashi syndrome

46
Q

Chediak-Higashi syndrome cells

A

phagocytes (granulocytes, monocytes)

occasional in lymphocytes

47
Q

seen in partial albinism

A

Chediak-Higashi syndrome

48
Q

Small lymphocytes with little cytoplasmic

projections

A

Hairy cells

49
Q

test for Hairy cells

A

TRAP - Tartrate Resistant Acid Phosphatase

50
Q

TRAP result for Hairy cells

A

(+)

51
Q

what is produced by Hairy cells to be tartrate reistant?

A
  • Isoenzyme 5
52
Q

may be seen in drug sensitivity

A

Tart cells

53
Q

monocyte that has ingested a whole

lymphocyte or a nucleus

A

Tart cells

54
Q

-Altered primary granules (present because

of rapid cell maturation)

A

toxic granulations

55
Q

toxic granulations appear like

A

Alder-reilly

56
Q

toxic granulation is seen in

A

severe infections and chemical poisoning (Lead poisoning)

57
Q

linear projections of primary granules (rod-like)

A

auer rods

58
Q

Auer rods seen in certain types of

A

AML

59
Q

Abnormal WBC with bundles of Auer rods in its cytoplasm

A

Faggot cell

60
Q

owl’s eyes

A

Reed-Sternberg cell

61
Q

what cell is a Reed-Sternberg cell

A

lymphoid cell

62
Q

definitive histiologic characteristic of Hodgkin’s disease

A

Reed-Sternberg cell

63
Q

-Poor neutrophil response to chemotactic

agents

A

Lazy leukocyte syndrome

64
Q

hyperimmunoglobulinemia E syndrome

A

Job syndrome

65
Q

characterized by recurrent severe
bacterial infections, skeletal abnormalities, and
elevated levels of IgE

A

Job syndrome

66
Q

presence of fat-containing vacuoles in granulocytes and monocyte

A

Jordan’s anomaly

67
Q

Jordan’s anomaly is seen in

A

muscular dystrophy & icthyosis

68
Q

Round or oval blue-staining cytoplasmic
inclusions found in neutrophils (arranged in
parallel rows and consisting of ribosomal
RNA)

A

Dohle bodies

69
Q

: pregnancy, severe burns, aplastic
anemia, scarlet fever and other infectious
diseases, and following administration of toxic
agents

A

dohle bodies

70
Q

appear like dohle bodies but with giant platelets

-gray-blue spindle shaped inclusions

A

May-Hegglin anomaly

71
Q

Dohle bodies vs MHA inclusions are diff. by

A

size
shape
PAS
Content

72
Q

Dohle bodies vs MHA inclusions:

PAS (+)

A

Dohle bodies

73
Q

Dohle bodies vs MHA inclusions

spindle-shaped

A

MHA inclusion

74
Q

Dohle bodies vs MHA inclusions:

larger in size

A

MHA inclusion

75
Q

Dohle bodies vs MHA inclusions:

contents

A

mRNA: MHA

ribosomal RNA : Dohle (“DR”)

hema - review (17 decks)

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