hematopoiesis Flashcards

1
Q

Hematopoiesis aka

A

Hemopoiesis

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2
Q

Hematopoiesis is defined as

A

the process of blood cell formation

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3
Q

classical marker of HSC

A

CD34

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4
Q

2 Related theories of origin of Hematopoietic progenitor cells

A
  1. Polyphyletic theory

2. Monophyletic theory

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5
Q

Theory that states that blood cells are derived from a single progenitor stem cell (pluripotential stem cell)
-most widely accepted theory

A

Monophyletic theory

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6
Q

phases of Hematopoiesis

A
  1. Mesoblastic/Megaloblastic
  2. Hepatic
  3. Intermedullary/ Medullary/ Myeloid
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7
Q

chief site of hematopoiesis in Mesoblastic/Megaloblastic

A

Yolk Sac

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8
Q

chief site of hematopoiesis in hepatic

A

Fetal Liver

*contribution of: Spleen, Thymus, Lymph nodes

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9
Q

chief site of hematopoiesis in Intermedullary/ Medullary/ Myeloid

A

Bone marrow

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10
Q

1st blood cells to appear in mesoblastic phase

A

Primitive Erythrocytes (RBCs)

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11
Q

embryonic hemoglobins

A

Gower 1
Gower 2
Portland

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12
Q

cells produced by kidneys and spleen in Hepatic phase

A

B cells

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13
Q

predominant hemoglobin in hepatic phase

A

Hb F

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14
Q

Sites of Adult hematopoiesis

A

Bone marrow
lymph nodes
spleen

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15
Q

Bursa of fabricus

A

birds’ primary lymphoid organ

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16
Q

a process of replacing red marrow by yellow marrow during development

A

Retrogression

17
Q

bones that have red marrow

A

RSVP

Ribs
Sternum, Skull, Shoulder Blades
Vertebrae
Pelvis & Proximal ends of long bones