hematopoiesis Flashcards
Hematopoiesis aka
Hemopoiesis
Hematopoiesis is defined as
the process of blood cell formation
classical marker of HSC
CD34
2 Related theories of origin of Hematopoietic progenitor cells
- Polyphyletic theory
2. Monophyletic theory
Theory that states that blood cells are derived from a single progenitor stem cell (pluripotential stem cell)
-most widely accepted theory
Monophyletic theory
phases of Hematopoiesis
- Mesoblastic/Megaloblastic
- Hepatic
- Intermedullary/ Medullary/ Myeloid
chief site of hematopoiesis in Mesoblastic/Megaloblastic
Yolk Sac
chief site of hematopoiesis in hepatic
Fetal Liver
*contribution of: Spleen, Thymus, Lymph nodes
chief site of hematopoiesis in Intermedullary/ Medullary/ Myeloid
Bone marrow
1st blood cells to appear in mesoblastic phase
Primitive Erythrocytes (RBCs)
embryonic hemoglobins
Gower 1
Gower 2
Portland
cells produced by kidneys and spleen in Hepatic phase
B cells
predominant hemoglobin in hepatic phase
Hb F
Sites of Adult hematopoiesis
Bone marrow
lymph nodes
spleen
Bursa of fabricus
birds’ primary lymphoid organ