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hema - review > Erythropoiesis > Flashcards

Erythropoiesis Flashcards

1
Q

Erythropoiesis

A

process of RBC formation

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2
Q

RBC survival determined by

A

labeling
the RBCs with
chromium-51 (51Cr),

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3
Q

normal rage of RBC survival det.

A

28 to 38 days

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4
Q

total mass of RBCs circulating in the peripheral blood AND the bone marrow RBC precursors

A

Erythron

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5
Q

a term that describes the dynamics of RBC creation and destruction

A

Erythrokinetics

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6
Q

mmature hematopoietic cells that is committed to a cell line but
CANNOT be identified morphologically

A

Progenitor cell

BFU-E, CFU-E

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7
Q

immature hematopoietic cell that is morphologically IDENTIFIABLE
as belonging to a given cell line

A

Precursor cells

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8
Q

EARLIEST marker of erythroid differentiation; transferrin receptor

A

CD71

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9
Q

primary target cells of EPO

A

BFU-E & CFU-E

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10
Q

3 major effects of EPO:

A

1.) allowing early release of reticulocytes from the bone marrow
2.) reducing the time needed for cells to mature in the bone marrow
3.) preventing apoptotic cell death (note: apoptosis rescue is the
MAJOR way in which EPO increases RBC mass)

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11
Q

primary cell source of EPO

A

Peritubular interstitial cells (kidneys)

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12
Q

GH is produced by

A

Anterior pituitary gland

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13
Q

GH function

A

stimulate erythropoiesis directly (BM)

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14
Q

testosterone function in erythropoiesis

A

stimulates indirectly

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15
Q

Prolactin produced by

A

Anterior pituitary gland

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16
Q

Prolactin function

A

stimulate erythropoiesis directly (BM)

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17
Q

estrogen effect on RBC count

A

lower

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18
Q

estrogen function

A

inhibits erythropoiesis

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19
Q

committed to eryhtroid progenitor cells

A

BFU-E & CFU-E

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20
Q

___ days for the BFU-E to mature to an erythrocyte

A

18 to 21 days

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21
Q

_____

are spent by BFU-Eas recognizable precursors in the bone marrow.

A

6 days

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22
Q

Retics found in Wright stain

A

Polychromatophilic Erythrocytes & Diffusely Basophilic Erythrocytes

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23
Q

rubriblast gives rise to ___ prorubricytes

A

2

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24
Q

earliest recognizable erythroid precursor using light microscope

A

Rubriblast

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25
Q

youngest of the precursor

A

Rubriblast

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26
Q

Rubriblast N:C ratio

A

8:1

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27
Q

nucleus takes up < 50%

A

lower ratio

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28
Q

nucleus takes up > 50%

A

ratio is higher

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29
Q

Prorubricyte N:C ratio

A

6:1

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30
Q

nucleoli in prorubricyte

A

0 to 1

31
Q

The prorubricyte gives rise to

________ rubricytes

A

4

32
Q

criteria in identifying prorubricyte from rubriblast

A

1) coarser chromatin

2) absence of nucleoli

33
Q

last stage with nucleolus

A

prorubricyte

34
Q

first stage of hemoglobinization (Hb synthesis)

A

prorubricyte

35
Q

Each of this cell (rubricyte) gives

rise to ___________ metarubricytes

A

2

36
Q

rubricyte is confused with

A

lymphocyte

37
Q

lymphocyte vs. rubricyte

A

L:
N-crushed velvet
C: sky-blue (robin egg”

R:
N- Checkerboard
C: muddy gray

38
Q

last stage capable of mitosis

A

rubricyte

39
Q

diffusely
lilac in color
(muddy
or gray)

A

rubricyte

40
Q

rubricyte N:C ratio

A

4:1

41
Q

pyknotic nucleus

A

Metarubricyte/Orthochromatic normoblast/Late normoblast

42
Q

Metarubricyte N:C ratio

A

1:2

43
Q

Metarubricyte other names

A

Nucleated RBC,
Pyknotic erythroblast,
Acidophilic normoblast

44
Q

salmon-pink

A

Metarubricyte

45
Q

last stage with nucleus

A

Metarubricyte

46
Q

Pyrenocytes contain

A

Howell-Jolly bodies

47
Q

last stage of hemoglobin synthesis

A

Reticulocyte

48
Q

polychromasia

A

Reticulocyte

49
Q

Retics Spends ___ day/s in the bone marrow

A

2 to 3

50
Q

retics spends ___ day/s in the Peripheral blood

A

1

51
Q

Shift Cells

A

Polychromatophilic macrocytes

52
Q

Polychromatophilic macrocytes/ shift cells seen in

A

cases of increased RBC production

53
Q

Stress Reticulocytes

A

macroreticulocytes

54
Q

Stress Reticulocytes seen in

A

more severe conditions like Hemolytic anemia

55
Q

mature erythrocytes appearance

A

biconcave disk,
1.5 to 1.5 um thick,
7 to 8 um,
120 days lifespan,

56
Q

or erythrocytes produced from each rubriblast

A

16

57
Q

normal ratio of RBC:WBC

A

600:1

58
Q

normal RBC:platelet ratio

A

15:1

59
Q

measures RBC survival

A

Chromium-51

60
Q

salmon-pink with central pallor occupying ___ the cell

A

1/3

61
Q

RBC membrane constituents:

A

8% carbohydrates, 40% lipids, and 52% proteins

62
Q

maintain membrane integrity

A

♦TRANSMEMBRANE PROTEINS

63
Q

Glucose transporter, supports ABH antigens

A

Glut-1

64
Q

Transports negatively charged sialic acid, supports MN

determinants

A

Glycophorin A

65
Q

Transports negatively charged sialic acid, supports

Ss determinants

A

Glycophorin B

66
Q

Transports negatively charged sialic acid, supports

Gerbich system determinants

A

Glycophorin C

67
Q

shape and flexibility of the erythrocyte

A

♦SKELETAL PROTEINS

68
Q

Primary cytoskeletal proteins

A

α-spectrin

β-spectrin

69
Q

MCHC value of Hereditary Spherocytosis patient

A

35-38mg/dL

70
Q

RBC in HS

A

stretchable but less elastic

71
Q

most sensitive and specific test to confirm the diagnosis of HS

A

-EMA binding test

72
Q

most

common form of stomatocytosis

A

Dehydrated hereditary
stomatocytosis
(Hereditary Xerocytosis)

73
Q

mutations that change MEMBRANE STRUCTURE

A

1) Hereditary spherocytosis
2) Hereditary elliptocytosis/pyropoikilocytosis
3) Hereditary ovalocytosis (Southeast Asian ovalocytosis)

74
Q

mutations that change MEMBRANE TRANSPORT PROTEINS

A

1) Overhydrated hereditary stomatocytosis

2) Dehydrated hereditary stomatocytosis or hereditary xerocytosis

hema - review (17 decks)

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