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hema - review > LEUKEMIA/LYMPHOMA > Flashcards

LEUKEMIA/LYMPHOMA Flashcards

1
Q

Most common Leukemia in Children

A

Acute Lymphocytic Leukemia (ALL)

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2
Q

Burkitt-type Leukemia

A

L3

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3
Q

ALL classification with cytoplasmic vacuoles

A

L3

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4
Q

Nucleolus of L3

A

2 - 5

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5
Q

PAS (-)
Methyl Green Pyronine (MGP) (+)
oro (+)

A

L3

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6
Q

Immunologic markers in ALL

A

E. rosettes
Surface Ig
Serum Anti-ALL

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7
Q

(+) E rosettes

A

T-ALL

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8
Q

Surface Ig (+)

A

B-ALL

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9
Q

Serum anti-ALL

A

Common ALL

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10
Q

Most common type of Leukemia in Elderly

A

Chronic Lymphocytic Leukemia

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11
Q

increased number of Smudge cells & Reider cells

A

CLL

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12
Q

Variations in CLL

A

 Lymphosarcoma cell leukemia
 Prolymphocytic leukemia
Hairy-cell leukemia

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13
Q

Lymphocytic Leukemia general result in MPO & SBB

A

Both Negative

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14
Q

Leukemia general characteristics

A

inc. WBC - shift to the left
M:E ratio 10:1
more blasts

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15
Q

type of anemia usually present in acute leukemia

A

normocytic normochromic

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16
Q

is it possible to perform an SBB stain on several months old slide?

A

YES

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17
Q

Fresh specimen is required and ligh sensitive staining

A

MPO

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18
Q

AML with myelcytic origine

A

M0, M1, M2, M3, M4, M6

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19
Q

AML with auer rod presence

A

M1, M2, M3, M4, M6

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20
Q

Naegeli monocytic leukemia

A

M4

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21
Q

M4E

A

AMML, with increased marrow eosinophils

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22
Q

Schilling Leukemia

A

M5

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23
Q

AMoL, well differentiated

A

M5b

-middle-aged adults
<80% monoblasts

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24
Q

Acute monocytic Leukemia

AMoL poorly differentiated

A

M5a

seen in children
>80% monoblasts in BM

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25
Q

DiGuglielmo’s syndrome

A

Acute Erythroleukemia / M6

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26
Q

Eryhtroid cells strongly PAS (+) in AML

A

Acute Erythroleukemia / M6

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27
Q

FACTOR VIII stain positive

A

M7

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28
Q

Acute Megakaryocytic leukemia

A

M7

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29
Q

requires immunocytochem for accurate diagnosis

A

M7

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30
Q

M7 origin

A

Megakaryocytic

31
Q

M6 origin

A

Erythrocytic

Myelocytic

32
Q

Monocytic origin

33
Q

2ND most common type of AML

34
Q

Butterfly
bowtie
apple core nuclei

35
Q

APL, microgranular variant

36
Q

associated with DIC

37
Q

Faggot cell associated

38
Q

MOST COMMON subtype of AML

A

AML, with maturation / M2

39
Q

AML, without maturation

40
Q

AML subtype:

MPO & SBB negative

41
Q

MACROCYTIC, NORMOCYTIC CELLS in this AML Subtype

A

M6 / Acute Erythroleukemia

42
Q

where do Myelocytic origin AML appear positive

A

MPO, SBB, SE

43
Q

where do Monocytic origin AML appear positive

A

NSE a & b

Butyrate & Acetate

44
Q

Chronic Myelogenous Leukemia aka

A

Chronic Granulocytic Leukemia

45
Q

what is present in CML

A

Philadelphia chromosome (Ph1)

46
Q

prognosis of patients with Ph1

A

good prognosis

47
Q

who discovered Philadelphia chromosome

A

Peter C. Nowell

48
Q

chromosomes in Philadelphia chromosome

49
Q

CML is differentiated from _______ by the use of _______

A 
Leukemoid reaction (LR);
LAP test
50
Q

WBC count in Leukemoid reaction

A

greater than 50 X 109/

51
Q

what do you mean by MARKED LEFT SHIFT?

A

presence of immature neutrophilic forms

52
Q

LAP/NAP test stands for

A

Leukocyte (Neutrophil) Alkaline Phosphatase Test

53
Q

INCREASED LAP is observed in neutrophils that have undergone

A

normal growth

54
Q

Method in LAP/NAP Test

A

Kaplow’s Method

55
Q

what presence is examined in the Kaplow’s method

A

reddish-brown to black precipitate in cytoplasm of neutrophils

56
Q

how many segmented neutrophils are counted in LAP test

A

100 segmented neutrophils

57
Q

heavily diffused reddish brown to black precipitate

58
Q

slightly diffused reddish brown to black precipitate

59
Q

moderately diffused reddish brown to black precipitate

60
Q

very heavily diffused reddish brown to black precipitate

61
Q

no reddish brown to black precipitate

62
Q

normal Kaplow’s score

63
Q

increased LAP score

A

Leukemoid Reaction

64
Q

decreased LAP score

65
Q

Disorders w/increased LAP score

A

1) Leukemoid Reaction
2) Polycythemia vera
3) infections
4) Intoxication

66
Q

Disorders w/decreased LAP score

A
  1. CML
  2. PNH
  3. Sideroblastic anemia
  4. Myelodysplastic syndrome
67
Q

type of lymphoma

A
  1. Hodgkin’s Disease/Lymphoma

2. Non-Hodgkin’s Lymphoma

68
Q

classification of hodgkin’s lymphoma

A
  1. Rye

2. WHO

69
Q

WHO Classification of Lymphoma

A
  1. Nodular lymphocyte predominant Hodgkin’s lymphoma (NLPHL)

2. Classical Hodgkin Lymphoma

70
Q 
Popcorn cell (L & H CELLS)
-Lymphocytic, Histiocytic
A

Nodular lymphocyte predominant Hodgkin’s lymphoma (NLPHL)

71
Q

subtype of classical hodgkinn’s lymphoma with Lacunar cells

A

Nodular sclerosis

72
Q

Non-hodgkin’s lymphoma associated with EBV

A

Burkitt’s lymphoma

73
Q

Non-hodgkin’s lymphoma associated with Sezary cell

A

CTCL (Cutaneous T cell lymphoma)

74
Q

most common CTCL (Cutaneous T cell lymphoma)

A

mycosis fundoides

hema - review (17 decks)

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