LEUKEMIA/LYMPHOMA

Question 1

Most common Leukemia in Children

Answer 1

Acute Lymphocytic Leukemia (ALL)

Question 2

Burkitt-type Leukemia

Answer 2

L3

Question 3

ALL classification with cytoplasmic vacuoles

Answer 3

L3

Question 4

Nucleolus of L3

Answer 4

2 - 5

Question 5

PAS (-)
Methyl Green Pyronine (MGP) (+)
oro (+)

Answer 5

L3

Question 6

Immunologic markers in ALL

Answer 6

E. rosettes
Surface Ig
Serum Anti-ALL

Question 7

(+) E rosettes

Answer 7

T-ALL

Question 8

Surface Ig (+)

Answer 8

B-ALL

Question 9

Serum anti-ALL

Answer 9

Common ALL

Question 10

Most common type of Leukemia in Elderly

Answer 10

Chronic Lymphocytic Leukemia

Question 11

increased number of Smudge cells & Reider cells

Answer 11

CLL

Question 12

Variations in CLL

Answer 12

 Lymphosarcoma cell leukemia
 Prolymphocytic leukemia
Hairy-cell leukemia

Question 13

Lymphocytic Leukemia general result in MPO & SBB

Answer 13

Both Negative

Question 14

Leukemia general characteristics

Answer 14

inc. WBC - shift to the left
M:E ratio 10:1
more blasts

Question 15

type of anemia usually present in acute leukemia

Answer 15

normocytic normochromic

Question 16

is it possible to perform an SBB stain on several months old slide?

Answer 16

YES

Question 17

Fresh specimen is required and ligh sensitive staining

Answer 17

MPO

Question 18

AML with myelcytic origine

Answer 18

M0, M1, M2, M3, M4, M6

Question 19

AML with auer rod presence

Answer 19

M1, M2, M3, M4, M6

Question 20

Naegeli monocytic leukemia

Answer 20

M4

Question 21

M4E

Answer 21

AMML, with increased marrow eosinophils

Question 22

Schilling Leukemia

Answer 22

M5

Question 23

AMoL, well differentiated

Answer 23

M5b

-middle-aged adults
<80% monoblasts

Question 24

Acute monocytic Leukemia

AMoL poorly differentiated

Answer 24

M5a

seen in children
>80% monoblasts in BM

Question 25

DiGuglielmo's syndrome

Answer 25

Acute Erythroleukemia / M6

Question 26

Eryhtroid cells strongly PAS (+) in AML

Answer 26

Acute Erythroleukemia / M6

Question 27

FACTOR VIII stain positive

Answer 27

M7

Question 28

Acute Megakaryocytic leukemia

Answer 28

M7

Question 29

requires immunocytochem for accurate diagnosis

Answer 29

M7

Question 30

M7 origin

Answer 30

Megakaryocytic

Question 31

M6 origin

Answer 31

Erythrocytic | Myelocytic

Question 32

Monocytic origin

Answer 32

M5

Question 33

2ND most common type of AML

Answer 33

M4

Question 34

Butterfly bowtie apple core nuclei

Answer 34

M3V

Question 35

APL, microgranular variant

Answer 35

M3V

Question 36

associated with DIC

Answer 36

M3

Question 37

Faggot cell associated

Answer 37

M3

Question 38

MOST COMMON subtype of AML

Answer 38

AML, with maturation / M2

Question 39

AML, without maturation

Answer 39

M1

Question 40

AML subtype: | MPO & SBB negative

Answer 40

M0

Question 41

MACROCYTIC, NORMOCYTIC CELLS in this AML Subtype

Answer 41

M6 / Acute Erythroleukemia

Question 42

where do Myelocytic origin AML appear positive

Answer 42

MPO, SBB, SE

Question 43

where do Monocytic origin AML appear positive

Answer 43

NSE a & b | Butyrate & Acetate

Question 44

Chronic Myelogenous Leukemia aka

Answer 44

Chronic Granulocytic Leukemia

Question 45

what is present in CML

Answer 45

Philadelphia chromosome (Ph1)

Question 46

prognosis of patients with Ph1

Answer 46

good prognosis

Question 47

who discovered Philadelphia chromosome

Answer 47

Peter C. Nowell

Question 48

chromosomes in Philadelphia chromosome

Answer 48

9 and 22

Question 49

CML is differentiated from _______ by the use of _______

Answer 49

``` Leukemoid reaction (LR); LAP test ```

Question 50

WBC count in Leukemoid reaction

Answer 50

greater than 50 X 109/

Question 51

what do you mean by MARKED LEFT SHIFT?

Answer 51

presence of immature neutrophilic forms

Question 52

LAP/NAP test stands for

Answer 52

Leukocyte (Neutrophil) Alkaline Phosphatase Test

Question 53

INCREASED LAP is observed in neutrophils that have undergone

Answer 53

normal growth

Question 54

Method in LAP/NAP Test

Answer 54

Kaplow's Method

Question 55

what presence is examined in the Kaplow's method

Answer 55

reddish-brown to black precipitate in cytoplasm of neutrophils

Question 56

how many segmented neutrophils are counted in LAP test

Answer 56

100 segmented neutrophils

Question 57

heavily diffused reddish brown to black precipitate

Answer 57

3+

Question 58

slightly diffused reddish brown to black precipitate

Answer 58

1+

Question 59

moderately diffused reddish brown to black precipitate

Answer 59

2+

Question 60

very heavily diffused reddish brown to black precipitate

Answer 60

4+

Question 61

no reddish brown to black precipitate

Answer 61

0

Question 62

normal Kaplow's score

Answer 62

20 - 100

Question 63

increased LAP score

Answer 63

Leukemoid Reaction

Question 64

decreased LAP score

Answer 64

CML

Question 65

Disorders w/increased LAP score

Answer 65

1) Leukemoid Reaction 2) Polycythemia vera 3) infections 4) Intoxication

Question 66

Disorders w/decreased LAP score

Answer 66

1. CML 2. PNH 3. Sideroblastic anemia 4. Myelodysplastic syndrome

Question 67

type of lymphoma

Answer 67

1. Hodgkin's Disease/Lymphoma | 2. Non-Hodgkin's Lymphoma

Question 68

classification of hodgkin's lymphoma

Answer 68

1. Rye | 2. WHO

Question 69

WHO Classification of Lymphoma

Answer 69

1. Nodular lymphocyte predominant Hodgkin's lymphoma (NLPHL) | 2. Classical Hodgkin Lymphoma

Question 70

``` Popcorn cell (L & H CELLS) -Lymphocytic, Histiocytic ```

Answer 70

Nodular lymphocyte predominant Hodgkin's lymphoma (NLPHL)

Question 71

subtype of classical hodgkinn's lymphoma with Lacunar cells

Answer 71

Nodular sclerosis

Question 72

Non-hodgkin's lymphoma associated with EBV

Answer 72

Burkitt's lymphoma

Question 73

Non-hodgkin's lymphoma associated with Sezary cell

Answer 73

CTCL (Cutaneous T cell lymphoma)

Question 74

most common CTCL (Cutaneous T cell lymphoma)

Answer 74

mycosis fundoides