W7 : Thyroid Disorder Drugs

Question 0

sx. of Hyperthyroidism

Answer 0

fast HT rate, nervousness, tremor and excess heat production

Question 1

sx of Hypothyroidism

Answer 1

slow heart rate, cold intolerance, physical slowing, (in children), hypothyroidisim can result in mental retardation and short stature.

Question 2

what is Levothyroxine (T4)(Synthroid)?

Answer 2

drug of choice for hypothyroidism

Question 3

what is MOA_Levothyroxine?

Answer 3

It replaces normal serum levels of T4 and T3.

*T4 is converted to T3 in the periphery.

Question 4

drugs to treat hyperthyroidism?

Answer 4

Methimazole (Tapazole)
Propylthiouracil (PTU)
Iodine/Iodide
Propranolol

Question 5

What is MOA_Methimazole (Tapazole)?

Answer 5

Inhibits iodination of tyrosine groups and coupling of these groups to form thyroid hormone.

Question 6

What is MOA_Propylthiouracil (PTU)?

Answer 6

Inhibits peripheral conversion of T4 to T3.

Question 7

What is MOA_Iodine/Iodide?

Answer 7

Inhibits release of thyroxine from thyroid gland.

Useful for 2 weeks then the gland adapts and resumes thyroxine secretion.

Question 8

What is MOA_Propranolol (Inderal)?

Answer 8

B- Blocker that suppresses tachycardia and other catecholamine effects.

Question 9

What is the use of B-Blocker, Propranolol in managing hyperthyroid patients?

Answer 9

Used for emergent preparation of hyperthyroid patients for surgery, thyrotoxicosis in pregnancy and thyroid storm.