W7 : Anticoagulants

Question 0

What is MOA_heparin and LMWH?

Answer 0

Interfere with the clotting factor activation in both the intrinsic and extrinsic pathways.
Bind to antithrombin III with the subsequent rapid inactivation of coagulation factors esp thrombin and Xa.

Question 1

What are classes of Anticoagulant drugs?

Answer 1

1. Heparin and LMWH (Low molecular weight heparin)
2. Oral anticoagulants
3. Thrombin inhibitors

Question 2

What is LMWHs?

Answer 2

Extracted from heparin that have larger anti-factor activities, greater bioavailability, longer half-life than heparin.

Question 3

What is the major adverse effect of anticoagulant drugs?

Answer 3

Hemorrhage

Question 4

What is the antidote for heparin poisoning?

Answer 4

Protamine

Question 5

What is MOA_oral anticoagulants such as warfarin (coumadin)?

Answer 5

Antagonize vit. K, interfere with the synthesis of vit K-dependent clotting factors (II, VII, IX, X)

Question 6

What is the antidote for oral anticoagulant?

Answer 6

administration of vit K can overcome the anticoagulant effects of the oral anticoagulants, but the effect takes about 24 hours.

Question 7

What is MOA_hirudin or argatroban?

Answer 7

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