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T7. Pharmacology > Drugs_anti HIV > Flashcards

Drugs_anti HIV Flashcards

0
Q

Lamivudine

A

Antiviral drug_HIV

Nucleosides (NRTIs)

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1
Q

Zidovudin

A

Antiviral drug_HIV

Neucleosides

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2
Q

Zidovudine + Lamivudine (Combivir)

A

given after accidental needle stick

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3
Q

Efavirenz

A

Antiviral drug_HIV

Nonnucleosides (NNRTIs)

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4
Q

Atazanavir

A

Antiviral drug_HIV

Protease inhibitor prevent formation of new viral particles

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5
Q

Fosamprenavir

A

Antiviral drug_HIV

Protease inhibitor; prodrug of amprevavir

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6
Q

Enfuvirtide

A

Antiviral drug_HIV

Fusion inhibitor block the binding of HIV to CD4 lymphocytes receptors that is required for HIV to enter cells

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7
Q

Raltegravir

A

Antiviral drug_HIV

Integrase inhibitor prevent integration of viral DNA into the DNA of the infected cells

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8
Q

2 RT inhibitor + 1 protease inhibitor

A

most effective tx of HIV

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9
Q

Amantadine

A

Antiviral_Influenza

Influenza type A infection prevention and treatment

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10
Q

Zanamivir

A

Antiviral drug_Neuraminidase inhibitors

Influenza A and B infection prevention and treatment

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11
Q

Acyclovir

A

Antiviral_Herpes
Herpes simplex type 1 and 2 (HSV-1, HSV-2)
Varicella zoster virus (VZV)
Epstein-Barr virus (EBV), Cytomegalovirus (CMV)- mono
*TOPICAL, IV, ORALLY for herpes infections

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12
Q

Foscarnet

A

Antiviral_herpes

approved for CMV retinitis, acyclovir-resistant HSV and VZV infections

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13
Q

Gancyclovir

A

Antiviral_herpes

Drug of choice for Cytomegalovirus infections

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14
Q

Aedefovir

A

Antiviral_hepatic viral

Hep B virus

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15
Q

Tenofovir

A

Antiviral_hepatic viral

Hep B virus

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16
Q

Pegylated interferon

A

Antiviral_hepatic viral
Hep B virus
inhibit viral RNA translation

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17
Q

Lamivudine

A

Antiviral_hepatic viral
Hep B virus
inhibitor of HBV DNA polymerase and HIV reverse transcriptase

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18
Q

Pegylated interferon alpha-2a

A

Antiviral_hepatic viral

Hep C infection

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19
Q

Pegylated interferon alpha-2b

A

Antiviral_hepatic viral

Hep C infection

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20
Q

Ribavirin

A

Antiviral_hepatic viral

Hep C infection

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21
Q

Cyclophosphamide

A

Anticancer drug
Alkylating agent
Most commonly used alkylating agent

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22
Q

u/e Cyclophosphamide

A

hemorrhagic cystitis

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23
Q

6-mercaptopurine

A

Anticancer drug

Antimetabolites

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24
Q

5-flurouracil

A

Anticancer

Antimetabolites

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25
Q

Methotrexate

A

Anticancer drug
Antimetabolites
Psoriasis, severe active rheumatoid arthritis in addition to whole variety of cancers
*administered intrathecally

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26
Q

Doxorubicin

A

Anticancer drug

Antibiotics

27
Q

u/e Doxorubicin

A

Cardiotoxicity, alopecia and bone marrow depression

28
Q

Bleomycin

A

Anticancer drug

Antibiotics

29
Q

u/e Bleomycin

A

fatal pulmonary fibrosis

*extreme caution- preexisting history of lung disease

30
Q

Plicamycin

A

Anticancer drug
Antibiotics
tx. Life-threatening hypercalcemia associated with malignancy

31
Q

Vincristine

A

Anticancer drug

Microtubule inhibitor

32
Q

u/e Vincristine

A

neurologic toxicity

33
Q

Vinblastine

A

Anticancer drug

Microtubule inhibitor

34
Q

u/e Vinblastine

A

bone marrow toxicity

35
Q

Anastrozole

A

Anticancer drug
Hormonal agent_aromatase inhibitor
tx. estrogen-dependent breast cancer resistant to tamoxifen

36
Q

Tamoxifen

A

Anticancer drug_Antiestrogen

tx. estrogen receptor positive breast cancer
* competitive antagonists of estrogen receptor

37
Q

Flutamide

A

Anticancer drug_androgen receptor antagonist

tx. prostate cancer

38
Q

Leuprolide

A

Anticancer drug_GnRh analog

tx. metastatic prostatic cancer

39
Q

Rituximab

A

Anticancer drug_monoclonal antibodies

tx. chronic lymphocytic leukemia

40
Q

Imatinib

A

Anticancer drug_other

tx. chronic myeloid leukemia

41
Q

Geftinib

A

Anticancer drug_other

tx. non small cell lung cancer

42
Q

Etoposide

A

Anticancer drug_other

tx. small cell carcinoma of the lungs

43
Q

Cisplatin and Cardbaplatin

A

Anticancer drug_other

tx. testicular carcinoma, ovarian carcinoma, bladder carcinoma

44
Q

Procarbazine

A

Anticancer drug_other

tx. Hodgkin’s disease

45
Q

L-asperginase

A

Anticancer drug_other

tx. childhood acute lymphocytic leukemia (ALL)

46
Q

Bacille Calmette-Guerin (BGC) vaccine

A

TB vaccine, effective in treating small localized superficial urinary bladder carcinoma
Intravesicular use
Non-specific stimulant of the reticuloendothelial system

47
Q

Asprin

A

Anti-inflammatory drug

Non selective inhibitors of cyclooxygenase

48
Q

u/e Asprin

A

Reye syndrome if given in viral infections, especially in children

49
Q

Diclofenac

A

Anti inflammatory drug

Non-selective inhibitors of cyclooxygenase

50
Q

Indomethacin

A

Anti inflammatory drug
Non selective inhibitors of cyclooxygenase
tx. in patent ductus arteriosus (PDA) in new born babies

51
Q

Celocoxib (Celebrax)

A

Anti inflammatory drug_selective COX-2 inhibitor

lower risk for GI bleeding, good for chronic use

52
Q

u/e Celocoxib (Celebrex)

A

hypertention

53
Q

Rofecoxib (Vioxx)

A

Anti inflammatory drug_selective COX-2 inhibitor

Withdrawn?

54
Q

Acetaminophen

A

Anti inflammatory drug_analgesics

antipyretic, analgesic; weak anti inflammatory activity

55
Q

Infliximab

A

Anti inflammatory drug_arthritis

Crohn’s disease

56
Q

Methotrexate

A

Anti inflammatory drug_disease-modifying anti-rheumatic drug

57
Q

D-Penicillamine

A

Anti inflammatory drug_disease-modifying anti-rheumatic drug

also tx. heavy metal poisoning, Wilson’s disease

58
Q

Aliopurinol

A

Gout

reduce uric acid formation

59
Q

Colchicine

A

Gout drug

tx. acute attack of gout

60
Q

Probenecid

A

Gout drug

uricosuric drug- increase uric acid excretion by the KD

61
Q

Cyclosprorine (CsA)

A

Immunosuppressive drug_selective inhibitors of cytokine production and fx
Prevention and treatment of transplanted organ rejections

62
Q

u/e Cyclosprorine (CsA)

A

nephrotoxicity, thromboembolism, neurotoxicity, seizure etc.

63
Q

Azathioprine

A

Immunosuppressive drug_immunosuppressive antimetabolites

t-cells and b-cells are particularly affected by the inhibition of purine synthesis

64
Q

Mycophenolate mofetil

A

Immunosuppressive drug_immunosuppressive antimetabolites

inhibits an enzyme that helps the growth of Tcells and Bcells

T7. Pharmacology (16 decks)

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