W7 : Hypothalamic and Pituitary Hormones

Question 0

What is Pegvisomant?

Answer 0

GH antagonist drug for gigantism and acromegaly

Question 1

What are the uses of growth hormone?

Answer 1

Replacement therapy in GH deficiency

Conditions having short stature, such as Turner’s syndrome

Question 2

What is Octreotide?

Answer 2

Somatostatin agonist drug for gigantism and acromegaly

Question 3

What is MOA_GH hormone (somatotropin)?

Answer 3

Bind to receptors on target cells and directly stimulate division and multiplication of chondrocytes of cartilage.
Stimulate the production of insulin-like-growth factor-1 from the LV (IGF-1 has effect on various tissues including osteoblasts and chondrocytes activity to promote bone growth).

Question 4

What group of drug is used for the treatment of hyperprolactinemia?

Answer 4

Prolactin_dopamine-receptor agonists

Question 5

What are the uses of Oxytocin?

Answer 5

To induce or reinforce labor.

Question 6

What are the uses of vasopressin?

Answer 6

Management of Diabetes insipidus

Management of septic shock

Question 7

What is MOA_vasopressin?

Answer 7

It produces antidiuretic effect by binding V2 receptors and increasing water reabsorption in the collecting tubules of the KDs.
It produces vasopressor effect by producing vasoconstriction.

Question 8

What is Terlipressin?

Answer 8

Vasopressin analogue

Used to treat bleeding esophageal varices