Sex Steroids Flashcards

0
Q

What are side effects of estrogen use?

A
  • most common: nausea and breast tenderness
  • endometrial hyperplasia, endometrial carcinoma, edema, weight gain, breast carcinoma, hyper pigmentation, thrombosis, myocardial infarction
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1
Q

What are the uses of estrogens?

A
  • most common in oral contraceptives
  • second most common is postmenopausal hot flashes and baginal atrophy
  • also used in replacement therapy for hypogonadism and osteoporosis
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2
Q

Name estrogenic drugs

A

Estradiol (estramaderm)
17 ethanol estradiol
Conjugated estrogens (Premarin)
Diethylstillbestrol (stilphostrol)

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3
Q

What is a potential complication of diethylatilboesterol in pregnancy?

A

Has been associated with cervical and vaginal carcinoma in the daughters of women who took the drug during pregnancy

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4
Q

Name the drugs considered SERMS

A

SERMS: mixed agonist antagonists of estrogen

Tamoxifen - antagonist to estrogen receptors in breast, estrogen agonist in uterus and bone

Raloxifene (evista) - agonist activity in bone, antagonist activity in breast and endometrium (used to treat osteoporosis)

Clomiphene (clomid) - partial estrogen receptor agonist in hypothalamus. Stimulates ovulation - used to treat female infertility

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5
Q

Use and MOA of tamoxifen

A

Used to treat estrogen sensitive breast cancer in post-menopausal women. MOA: antagonist to estrogen receptors in the breast but agonist to receptors in bone and uterus. Prevents endogenous estrogens from stimulating tumor growth.

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6
Q

Use and MOA of raloxifene

A

Used to treat and prevent osteoporosis. MOA: has agonist activity in bone and antagonist in breast and endometrial tissue. Binds to estrogen receptors and induces expression of gene that maintains bone density.

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7
Q

Use and MOA of clomiphene

A

Used to treat female infertility by stimulating ovulation. MOA: partial estrogen receptor agonist in the hypothalamus. Interferes with the negative feedback mechanism by binding to estrogen receptors and makes hypothalamus sense a lack of estrogen. This results in release of more gonadotropins and GnRH which stimulate ovulation.

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8
Q

What are the uses and side effects of progesterone drugs?

A

Oral contraceptives, replacement therapy, treatment of dysfunctional uterine bleeding, dysmennorhea, and endometriosis

Side effects: weight gain, edema, depression, increased clotting (leading to possible thrombophlebitis or pulmonary embolism)

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9
Q

What is the use and MOA of mifepristone?

A

Works to terminate pregnancy by breaking down the uterine lining

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10
Q

Which population of women taking oral contraceptives has increased incidence of abnormal clotting?

A

Women who smoke and who are over the age of 35

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