W7 : Antihyperlipidemic Drugs

Question 0

What are the drugs of first choice for the treatment of hypercholesterolemia?

Answer 0

HMH-CoA reductase inhibitors

Question 1

What are classes of Antihyperlipidemic drugs?

Answer 1

1. HMG-CoA reductase inhibitors
2. Fibrates
3. Niacin (Nicobid)
4. Bile acid sequestrants
5. Cholesterol absorption inhibitors

Question 2

What is Simvastatin (Zocor)?

Answer 2

HMG-CoA reductase that decrease cholesterol, LDL, VLDL, and Triglycerides, and increase HDL

Question 3

What is Atrovastatin (Lipitor)?

Answer 3

Most potent HMG-CoA reductase that decrease cholesterol, LDL, VLDL, and Triglycerides, and increase HDL

Question 4

What is Rosuvastatin (Cerstor)?

Answer 4

Most potent HMG-CoA reductase that decrease cholesterol, LDL, VLDL, and Triglycerides, and increase HDL

Question 5

What are adverse effects of HMG-CoA reductase?

Answer 5

LV Fx abnormalities, myopathy, rhadbomyolysis (disintegration of muscle), etc.
*NO GRAPEFRUIT JUICE

Question 6

What is MOA_HMG-CoA reductase?

Answer 6

Inhibit HMG-CoA reductase, which controls the rate-limiting step in cholesterol synthesis

Question 7

What is MOA_Niacin?

Answer 7

Strongly inhibits lipolysis in adipose tissue–> decrease cholesterol, TG, LDL, VLDL and increases HDL

Question 8

What is adverse effects of Niacin?

Answer 8

Flush and pruritus

Question 9

What is MOA_bile acid sequestrants?

Answer 9

Bind bild acids in the SI, prevent their reabsorption

• -> LV use cholesterol to make more bile acids
• -> decrease cholesterol and LDL, increase TG and HDL

Question 10

What is Cholestyramine (Questran)?

Answer 10

Bile acid sequestrant

Question 11

What is MOA_Ezetimibe?

Answer 11

Inhibit intestinal absorption of dietary and biliary cholesterol
–> decrease of LDL & TG, increase HDL