W7 - Excretion Flashcards
What are the 3 forms excretion can be in
fluids
solid
gasses
what are some example of fluid excretion
urine bile sweat tears breast milk
what are some examples of solid excretion
faces , hair
what are some examples of gas excretion
expired air
What are the 3 components of renal excretion
glomerular
reabsorption
tubular secretion
how do we calculate total renal excretion
Glomerular filtrate + tubular secretion - reabsorption
what size molecules are allowed to pass through the glomerulus
20kDa molecule and below
Where are the renal tubule secretory transporters
both basolateral and apical membrane
what do the secretory transporters do
transport acidic organic transporters or basic compounds
It can result rapid decrease in plasma concentration of unbound drug causing a rapid dissociation of any drugs bound to protiens in the plasma
What factors affect excretion
blood flow
kinetics