W7 - Distribution Flashcards

1
Q

What is the volume of distribution

A

Volume of fluid required to contain the total amount of drug in the body at the same concentration as that present in the plasma

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2
Q

What is the unit of Vd

A

Litres but can be normalised against body weight so become Litres/Kg

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3
Q

What is the minimum amount of Vd

A

it cannot be smaller than the physiological volume of intravascular plasmsa which is roughly 3L

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4
Q

What does the distribution of drugs depend on

A

Physiochemical feature

Pharmacological features

Blood Flow in organ/ Tissue

Barriers of organ / tissue

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5
Q

what are the 2 main physiochemical features of the drug

A

size of drug molecule

pKa of drug

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6
Q

What fraction of a drug is therapeutically active

A

only unbound fractions of drug are therapeutically active

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7
Q

what is the rate at which a drug is distributed dependent upon

A

the rate at which a drug is distributed to various organs depends on the proportion of cardiac output to the target.

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