27 Drug Delivery of CV

Question 1

What cardiovascular conditions do i need to know

Answer 1

angina
arrhythmias
heart failure
hypertension
lipid regulation
myocardial infarction
pericarditis
peripheral artery disease
stroke

Question 2

the type of formulation chosen depends on two factors when producing a delivery strategy for cv drugs

Answer 2

onset of action needed

nature of the disease

Question 3

describe the delivery using the paternal route

Answer 3

drug is directly introduced into the blood meaning a fast onset and bypasses the first pass metabolism

can be given via bolus or infusion intramuscular or subcutaneous

Question 4

describe the delivery using the sublingual route

Answer 4

drug is taken under the drug as it passes through the thin mucosa of the sublingual region as it is rich blood supply

it has a fast onset however it is not often suitable for all drugs

Question 5

what properties should a drug that is to be used sublingually have

Answer 5

drug should be potent
water soluble
relatively small molecular weight

Question 6

describe the delivery using the transdermal route

Answer 6

sustained release of the drug
compliance and less eratic absorption
onset of action is not critical

Question 7

describe the structure of a patch

Answer 7

impermeable tan coloured backing film

drug reservoir

semi permeable release membrane that controls the release to the skin

layer of silicone adhesive

a white to off white coloured protective liner which is removed prior to usse

Question 8

describe the delivery using the oral route

Answer 8

reserved for chronic stable conditions
same absorption conditions
onset of action is not critical
opportunity to modify the drug release