W5 - Chemistry of GPCR's Flashcards
What are the two types of bonding
intramolecular bonding
Intermolecular bonding
what is intramolecular bonding
bonding within the same molecule
What is intermolecular bonding
bonding between two neighboring molecules non covalent
What type of bonding is involved in drug binding interactions
intermolecular
what are the main types of intermolecular bonding
electrostatic Hydrogen bonding van der waals dipole dipole & ion dipole Repulsive forces Pi stacking
What are the two hypothesis for binding of substrates
Lock and Key
Induced fit
What is lock and key hypothesis
The substrate and binding site are complementary to each other therefor a perfect fit for eachother however this does not explain multiple substrate
What is the induced fit theory
substrate and active sit not exactly complementary however binding interactions cause the active site to change and become complementary
What does GPCR stand for
G protein coupled receptors
What do GPCR’s respond to
Hormones and slow acting neurotransmitters
What type of proteins are GPCR’s
Membrane bound proteins
What do GPCR’s do
activate membrane bound enzymes through G protein signalling
What does the mechanism of activation rely on
Induced fit of messenger changing the shape of the protein
What do inhibitors prevent
prevent the changing of the shape stopping the receptor being activated
Describe how the inhibitors work
They have an antagonist design
