Viruses and AntiVirals Flashcards

1
Q

killed vaccines

A

Rabies, influenza (injected), salk polio, HAV

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2
Q

the only ssDNA virus

A

Parvo

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3
Q

DNA viruses

A

HHAPPPPy: Hepadna, Herpes, adeno, pox, parvo, papilloma, polyoma

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4
Q

DNA viruses replicate where (and exception)

A

in nucleus except poxvirus (DNA-dep RNA pol)

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5
Q

only dsRNA virus

A

reovirus

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6
Q

RNA viruses

A

I went a RETRO TOGA party to drink FLAVored CORONA and ate HEPE (hippy) CALIfornia (calicivirus) PICORA (picorna)

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7
Q

ploidy of viruses

A

all are haploid except retroviruses (diploid)

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8
Q

Non-enveloped viruses

A

Hepe CPR (RNA), PAPP (DNA)
Calcivirus, Parvo, Reo
Papilloma, Adeno, Picorna, Polyoma

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9
Q

HSV1

A
#1 cause of encephalitis (temporal lobe), oral/facial, keratoconjunctivitis, latent in trigeminal 
not STD, saliva
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10
Q

HSV2

A

genital herpes, neonatal, latant in sacral ganglia

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11
Q

VZV

A

HHV3: shingles/chickenpox, also encephalitis and pneumonia. latant in dorsal root or trigem ganglia

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12
Q

EBV

A

HHV4: mononucleosis (kissing), Burkitt’s/Hodgkins lymphoma, nasopharyengocarcinoma, infects B cells, pharyngitis, hepatosplenomegaly, atypical T cells on smear, monospot test

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13
Q

CMV

A

HHV5: babies, monospot negative mononucleosis, retinitis (sight-o megalovirus), owls eyes inclusions, latent in mononuclear cels

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14
Q

HHV6

A

Roseola: high fever, seizures followed by diffuse macular rash

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15
Q

HHV8

A

Kaposi sarcoma seen in HIV. purple papules on skin and oral mucosa

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16
Q

Adenoviruses cause

A

DNA virus: pink eye (conjunctivitis), pneumonia, pharyngitis

17
Q

Parvovirus

A

DNA virus
B19: aplastic crisis in sickle cell, fifth disease (slapped cheeks erythema), Rheumatoid arthritis, RBC destruction in fetus to cause hydrops fetalis

18
Q

Polyomaviruses

A

DNA
JC: PML in AIDS
BK: kidney in transplant patients

19
Q

Poxviruses

A

DNA Virus:
Smallpox
Vaccinia (cowpox)
Molluscum contagiosum (flesh dome)

20
Q

Genetic material of Herpes HHV/HSV

21
Q

live vaccines

A

smallpox, YFV, chicken pox, Sabin polio, MMR, Influ

22
Q

zanamivir, oseltamivir

A

inhibits influenza neuraminidase decreasing release of progeny

23
Q

ribavirin mech and use

A

inhibits guanine nucleotide synthesis by blocking IMP dehydrogenase. RSV and chronic hepatitis C

24
Q

acyclovir mech and use

A

Monosphorylated by HSV/VZV thymidine kinase, viral DNA chain termination. Herpes viruses HSV1/2 and VZV. Weakly EBV, no activity with CMV. used for controling lesions and encephalopathy and prophalaxis

25
Ganciclovir mech and use
5' Monophosphate formed by CMV kinase, Guanosine analog. used in CMV immunocompromized.
26
Foscarnet
viral DNA pol inhibitor/binds pyrophosphate site (no need for viral activation). used in CMV and HSV which have resistance since it doesn't need viral kinase. Pyrophosphate analog .
27
Cidofovir
inhibits viral DNA pol, doesn't need viral kinase