Viruses and AntiVirals

Question 1

killed vaccines

Answer 1

Rabies, influenza (injected), salk polio, HAV

Question 2

the only ssDNA virus

Answer 2

Parvo

Question 3

DNA viruses

Answer 3

HHAPPPPy: Hepadna, Herpes, adeno, pox, parvo, papilloma, polyoma

Question 4

DNA viruses replicate where (and exception)

Answer 4

in nucleus except poxvirus (DNA-dep RNA pol)

Question 5

only dsRNA virus

Answer 5

reovirus

Question 6

RNA viruses

Answer 6

I went a RETRO TOGA party to drink FLAVored CORONA and ate HEPE (hippy) CALIfornia (calicivirus) PICORA (picorna)

Question 7

ploidy of viruses

Answer 7

all are haploid except retroviruses (diploid)

Question 8

Non-enveloped viruses

Answer 8

Hepe CPR (RNA), PAPP (DNA)
Calcivirus, Parvo, Reo
Papilloma, Adeno, Picorna, Polyoma

Question 9

HSV1

Answer 9

#1 cause of encephalitis (temporal lobe), oral/facial, keratoconjunctivitis, latent in trigeminal 
not STD, saliva

Question 10

HSV2

Answer 10

genital herpes, neonatal, latant in sacral ganglia

Question 11

VZV

Answer 11

HHV3: shingles/chickenpox, also encephalitis and pneumonia. latant in dorsal root or trigem ganglia

Question 12

EBV

Answer 12

HHV4: mononucleosis (kissing), Burkitt’s/Hodgkins lymphoma, nasopharyengocarcinoma, infects B cells, pharyngitis, hepatosplenomegaly, atypical T cells on smear, monospot test

Question 13

CMV

Answer 13

HHV5: babies, monospot negative mononucleosis, retinitis (sight-o megalovirus), owls eyes inclusions, latent in mononuclear cels

Question 14

HHV6

Answer 14

Roseola: high fever, seizures followed by diffuse macular rash

Question 15

HHV8

Answer 15

Kaposi sarcoma seen in HIV. purple papules on skin and oral mucosa

Question 16

Adenoviruses cause

Answer 16

DNA virus: pink eye (conjunctivitis), pneumonia, pharyngitis

Question 17

Parvovirus

Answer 17

DNA virus
B19: aplastic crisis in sickle cell, fifth disease (slapped cheeks erythema), Rheumatoid arthritis, RBC destruction in fetus to cause hydrops fetalis

Question 18

Polyomaviruses

Answer 18

DNA
JC: PML in AIDS
BK: kidney in transplant patients

Question 19

Poxviruses

Answer 19

DNA Virus:
Smallpox
Vaccinia (cowpox)
Molluscum contagiosum (flesh dome)

Question 20

Genetic material of Herpes HHV/HSV

Answer 20

DNA

Question 21

live vaccines

Answer 21

smallpox, YFV, chicken pox, Sabin polio, MMR, Influ

Question 22

zanamivir, oseltamivir

Answer 22

inhibits influenza neuraminidase decreasing release of progeny

Question 23

ribavirin mech and use

Answer 23

inhibits guanine nucleotide synthesis by blocking IMP dehydrogenase. RSV and chronic hepatitis C

Question 24

acyclovir mech and use

Answer 24

Monosphorylated by HSV/VZV thymidine kinase, viral DNA chain termination. Herpes viruses HSV1/2 and VZV. Weakly EBV, no activity with CMV. used for controling lesions and encephalopathy and prophalaxis

Question 25

Ganciclovir mech and use

Answer 25

5’ Monophosphate formed by CMV kinase, Guanosine analog. used in CMV immunocompromized.

Question 26

Foscarnet

Answer 26

viral DNA pol inhibitor/binds pyrophosphate site (no need for viral activation). used in CMV and HSV which have resistance since it doesn’t need viral kinase. Pyrophosphate analog .

Question 27

Cidofovir

Answer 27

inhibits viral DNA pol, doesn’t need viral kinase