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Step Uno > Autonomic Drugs > Flashcards

Autonomic Drugs Flashcards

1
Q

Vesamicol mech

A

blocks ACh packaging into vesicles

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2
Q

Bethanechol: type, effect, uses

A

Acetylcholine direct agonist, activates bowel and bladder (resistant to esterase), post operative ileus/urine retention

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3
Q

Carbachol: type, effect, uses

A

direct ACh agonist, exact mimic of ACh, glaucoma, pupillary contraction, relief of high IOP

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4
Q

Pilocarpine: type, effect, uses

A

ACh direct agonist, stimulates sweat/tears/saliva, used in glaucoma

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5
Q

Methacholine: type, effect, uses

A

direct ACh agonist, stims muscarinic rec in airway, test for asthma

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6
Q

Neostigmine: type, effect, uses

A

anticholinesterase, no CNS, post op/neuro ilius and urinary retention, Myasthenia gravis, reversal of NMJ blockade

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7
Q

pyridostigmine: type, effect, uses

A

Acetylcholinesterase inhibitor, just better neostimine that last longer, Myasthenia gravis, again no CNS

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8
Q

Edrophonium: type, effect, uses

A

anticholinesterase, short acting used to test for myasthenia gravis

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9
Q

Physostigmine: type, effect, uses

A

anticholinesterase which crosses into CNS, treat atropine overdose

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10
Q

Donepezil: type, effect, uses

A

Anticholinesterase, Alzheimers

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11
Q

insecticide/organophosphate poisoning

A

inhibit irreversibly AChE DUMBBELSS: Diarrhea, Urination, Miosis, Bronchospasm, Bradycardia, Excitation of skeletal muscles/cns, Lacrimation, Sweating, Salivation

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12
Q

treatment of organophophate poisoning

A

atropine + pralidoxime

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13
Q

Benzotropine: type, effect, uses

A

muscarinic antagonist, CNS, parkinsons (park my benz)

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14
Q

Scopolamine: type, effect, uses

A

muscarinic antagonist, CNS, motion sickness

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15
Q

Ipratropium/tiotriopium: type, effect, uses

A

muscarinic antagonist, resp, COPD/asthma

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16
Q

oxybutynin: type, effect, uses

A

muscarnic antagonist, genitourinary, reduce urgency in cystitis and bladder spasms

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17
Q

glycopyrrolate: type, effect, uses

A

GI, resp, pre-op airway (reduce secretions), oral (drooling/peptic ulcers)

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18
Q

Atropine mech and typical uses

A

THE muscarinic antagonist, treat bradycardia and opthalmic applications

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19
Q

Atropine effects on eye, airway, stomach, gut, bladder

A

eye: increase pupil dilation, cycloplegia
airway: decrease secetions
stomach: decrease acid
gut: decrease motility
bladder: decrease urgency in cystitis

20
Q

Atropine toxicity

A

Hot as a hare, Dry as a bone, Red as a beet, Blind as a bat, Mad as a hatter
glaucoma (old), urinary retention (BPH), hyperthermia (infants)

21
Q

Epi: receps, app

A

strong alpha and beta, anaphylaxis, glaucoma, asthma, hypotension

22
Q

alpha1

A

sympathetic, vasconstrict, dilate pupil, contract sphincters

23
Q

alpha2

A

sympathetic, decrease insulin/lipolysis, increase plate agg

24
Q

beta1

A

sympathetic, increase heart rate/contractility/renin/lipolysis

25
Q

beta2

A

sympathetic, vasodilate, bronchodilate, increase heart rate/contractility/lipolysis/insulin/aqueous humor production, decrease uterine tone

26
Q

muscarinic M1,2,3 diff

A

1: CNS/enteric 2:slow heart 3:increase exocrine/gut

27
Q

Dopamine D1v2

A

1: relax renal
2: modulate CNS NT release

28
Q

Histamine H1v2

A

1: nasal/bronchial mucus and constriction/pain
2: gastric acid secretion

29
Q

Vasopressin V1/2

A

1: vascular contraction
2: kidney water reabsorption

30
Q

alpha1/2, beta1/2, M1/2/3/, D1/2, H1/2, V1/2 are what kinda receptors?

A

GPCRS (qiss, qiq, siq, sqs)

31
Q

Norepi: receps, app

A

only alpha1/2, hypotension (but decreases renal perfusion)

32
Q

Isoproterenol: receps, app

A

only stims beta1/2, torsades de pointes, bradyarrhythmias

33
Q

dopamine: receps, app

A

D1/2 low dose, then betas, then alphas at highest doses. used for shock, heart failure

34
Q

Phenylephrine: receps, app

A

weakly stims only alpha1(little bit 2), decongestant, hypotension (vasconstrict), occularprocedures (mydratic)

35
Q

Dobutamine: receps, app

A

only beta1, heart failure, cardiac stress testing

36
Q

Albuterol,salmeterol,terbutaline: receps, app

A

only beta2, acute asthma. terb used to reduce uterine contractions

37
Q

ritodrine: receps, app

A

beta2 only, reduce uterine contractions

38
Q

amphetamine action

A

releases stored catecholamines

39
Q

Ephedrine mech

A

releases stored catecholamines

40
Q

cocaine mech

A

reuptake of catecholamines inhibitor. local anesthesia. NEVER GIVE BETA BLOCKERS

41
Q

clonidine/alpha-methyldopa

A

central alpha2-antagonist, hypertension treatment (no effect on renal flow though)

42
Q

Phenoxybenzyamine

A

irreversible alpha blocker, pheochromocytoma

43
Q

Phentolamine

A

reversible alpha antagonist, people who took MAOi and at tyramine foods

44
Q

Prazosin, terazosin, (-osin)

A

alpha1-antagonist, treat hypertension/urinary retention

45
Q

Mirtazapine

A

alpha2-selective antagonist, treat depression

46
Q

Hemicholinium mech

A

blocks choline uptake

Step Uno (30 decks)

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