Reproductive Drugs

Question 1

leuprolide

Answer 1

GnRH analog. pulsatile = agonist. continuous= antagonist. agonist function for infertility. antagonist function for prostate cancer, precocious puberty

Question 2

prostate cancer treatment

Answer 2

flutamide + continuous leuprolide

Question 3

treatment of hypogonadism and promote recovery from burns

Answer 3

testosterone, methyltestosterone

Question 4

flutamide

Answer 4

nonsteroidal competitive inhib of androgens at testosterone receptor

Question 5

ketoconazole and spironolactone use

Answer 5

polycystic ovarian syndrome treatment to prevent hirutism

Question 6

estrogens (ethinyl estradiol, DES, mestranol) uses

Answer 6

hypogonadism or ovarian failure, menstrual abnormalities, HRT in postmenopausal, and androgen-dependent prostate cancer

Question 7

estrogens (ethinyl estradiol, DES, mestranol) toxicity

Answer 7

risk of endometrial cancer, bleeding in postmenopausal women, clear cell adenocarcinoma vaginal when DES in utero, risk of thrombi

Question 8

clomiphene mech and use

Answer 8

partial agonist of estrogen receptor in hypthalamus to prevent feedback inhibtion. used to treat infertility, and polycystic ovarian syndrome.

Question 9

clomiphene toxicities

Answer 9

hot flashes, ovarian enlargment, multiple simultaneous pregnancies, and visual distrubances

Question 10

tamoxifen

Answer 10

ER antagonist in breast tissue for ER positive breast cancer

Question 11

Roloxifene

Answer 11

ER agonist in bone to reduce resorption of bone. osteoporosis

Question 12

anastrozole/exemestane

Answer 12

aromatase inhibitor used in postmenopausal women with breast cancer

Question 13

progestins

Answer 13

used in OCP and endometrial cancer treatment and uterine bleeding. bind progetstrone receptors

Question 14

mifepristone

Answer 14

inhibits progesterone recptor (competitive). termination of pregnancy in combo with misoprostol (PGE1)

Question 15

terbutaline

Answer 15

beta(2)-agonist that relaxes uterus to prevent premature uterine contractions

Question 16

sildenail/vardenafil toxiicty

Answer 16

penis pill. headache, flushing, dyspepsia (heartburn), loss of blue-green vision, hypotension in patients taking nitrates (life threatening)

Question 17

Danazol

Answer 17

synthetic androgen which acts as a partial agonist at androgen receptors. used in endometriosis and hereditary angioedema.