viruses and antivirals Flashcards
how big are viruses
30-500 nm
what do virussies contain
dna rna or nucleic acid in a protein coat
give some basic information about tobacco mosaic viruss
filamentus bacteria
single stranded 4 gene rna
replicase
rna dependant polymerase
movementr protien
capsid
why are icosahedrons or cylinders the main viral shapes
incredibly simple, reduces number of protiens required
what is a single viral protein called
virion
what are some components of a virus
genetic material, capsid, nucleoprotein, envelope, matrix, peplomers(spikes)
what are the components of hiv
outer membrane consisting of 72 glycoprotein spikes
matrix of p17
capsid of p24s
human cyclophilin a bound to p24
2 copies of single stranded rna
nucleocapsid sheath of p9 with the rna
reverse transcriptase
hiv protease
hiv intergrase
what are some features of the hiv genome
has 9 genes
spans 9.2 kbp
has some overlapping and fragmented genes
what makes rna viruses and retroviruses tricky
high mutation, no proofreading
what are the stages of hiv replication
adhesion
penetration
uncoating(undressing)
reverse transcription
genome replication
viiral rna export
viral protein synthesis
virion packaging
virion release
what aspects do hiv drugs target
entry
reverse transcriptase inhibitors
protease inhibitors
how does azt function
competetive inhibitor of reverse transcriptase
