lung 3: asthma Flashcards
how many people recieve treatment for and die from asthma
5.4 million
2000
what is asthma
immune response triggered by innocuous antigens
it is episodic and the severity increases over time
what are the clinical symptoms of athsma
shortness of breath
wheezing
cough
what causes the airflow obstruction found in asthma
bronchoconstriction
mucus hypersecretion
airway hyper responsiveness
what is bronchorestriction
smooth muscle contraction in airways
is airflow limitation reversible
only partially, which leads to increased severity over time
what are the phases of atopic asthma
1.sensitisation to allergen
2.early phase response
3.late phase response
4.airway remodelling
which immune cells are involved in early sensitisation
dentritic cells
what cytokine is produced by t cells during late stage asthma
il4 to produce ige molecules
are there more or less mast cells in asthmatics
more
what are mast cells filled with
granules filled with inflammatory media
what happens when allergen binds to mast cells
degranulation
which leukocyte is responsible for late stage asthma
eosinophils
what are the inflammatory mediators released by mast cells
prostoglandins and leukotriens
what are two forms of asthma treatment
anti inflammatory and bronchodilations
