Virus Lecture 20 Flashcards
What DNA virus has reverse transcriptase?
Hepadnaviridae
Retro
Reverse/backward reflects the property of retroviruses to use their RNA genome to produce DNA intermediates using reverse transcriptase, an RNA-dependant DNA polymerase
What was the first retrovirus described?
Equine infectious anemia
What is unique about the retrovirus genome?
Diploid (pseudodiploid), consisting of a dimer of two molecules of linear positive-sense, single-stranded RNA
The linear DNA forms integrate into cellular chromosomal DNA as a?
Provirus
Oncogenic retrovirus is?
A retrovirus with the gene that has the potential to cause cancer.
How is equine infectious anemia transmitted?
Mechanically transmitted through stable fly
What does equine infectious anemia infect.
Infects monocytes and macrophages
Name the retrovirus in cats?
Feline immunodeficiency virus
How is feline immunodeficiency virus transmitted?
Through bite injuries
What does feline immunodeficiency virus infect?
Depletion of CD4 positive T helper cells
What RNA virus is enveloped, bullet shaped, helically coiled, and nucleocapsid?
Rhabdoviridae
What is the genus for Rhabdoviridae?
Lyssavirus
What virus is rabies virus?
Rhabdoviridae
To diagnose rabies what is looked for?
Infected neurons contain intracytoplasmic inclusion bodies called Negri bodies.
What animals get rabies? (according to our teacher)
Dogs, cats, wild canid and felids, vampire bats, mongoose
What virus is pleomorphic or filamentous?
Filoviridae: Ebolavirus
What is the progression of disease with Filoviridae: Ebolavirus?
Monocyte infection > release of cytokines>endothelial injury>haemorrhage
What virus has genomes composed of several (6-8) segemnts of single- stranded RNA?
Orthomyxoviridae
What does Orthomyxoviridae cause?
Influenza and Glycoprotein spikes
H=Hemagglutinin (HA)
N=Neuraminidase (NA)
For Orthomyxoviridae what is the difference between antigenic shift and antigenic drift?
Antigenic shift is a reassortment of segments of genes
Antigenic drift is a mutation of genes.
The Picornaviridae causes what disease in animals and what disease in humans?
Animals: Aphthovirus (foot and mouth)
Humans: Enterovirus (human poliovirus)
Which virus is enveloped with spikes called peplomeres?
Coronaviridae
What disease are caused by Coronaviridae in cats and humans?
Cats: Feline enteric coronavirus (feline infectious peritonitis virus)
Humans: SARS (Sever acute respiratory syndrome)
What virus causes West Nile virus?
Flaviviridae, flavivirus
What are the two virus that are arthropod borne?
Flaviviridae and Swine Pox
What is the genus name for bovine viral diarrhea virus and classic swine fever in the family Flaviviridae?
Pestivirus
Who are dead end hosts for arthropod borne virus?
Humans and horses
T:F Bovine viral diarrhea virus is a laten infection.
False
Bovine viral diarrhea virus is a persistent infection.
What disease are caused by Togaviridae?
Alphavirus Eastern equine encephalitis virus Western equine encephalitis virus Highlands J virus Venezuelan equine encephalitis virus
What is an arbovirus?
Arthropod borne virus, replicates and transmitted by arthropods
What virus causes canine distemper?
Paramyxoviridae
