Virology 2

Question 1

1 cause of sporadic encephalitis in the U.S. (What kind of encephalitis?)

Answer 1

HSV-1, temporal lobe encephalitis

Question 2

Where does latent HSV-1 reside?

Answer 2

trigeminal ganglion

Question 3

Where does latent HSV-2 reside?

Answer 3

Sacral ganglia

Question 4

How is VZV spread?

Answer 4

Respiratory secretions

Question 5

Where does latent VZV reside?

Answer 5

Dorsal root OR trigeminal ganglia

Question 6

3 neoplasms caused by EBV

Answer 6

Hodgkin’s lymphoma, Burkitt’s lymphoma, and Nasopharyngeal carcinoma

Question 7

Test for EBV

Answer 7

Monospot test (heterophile antibody test)

Question 8

Where does latent EBV reside

Answer 8

B cells

Question 9

typical CMV-infected cell appearance

Answer 9

owl-eye inclusions

Question 10

Where does latent CMV reside?

Answer 10

mononuclear cells

Question 11

Describe the disease that HHV-6 causes.

Answer 11

Roseola (Sixth’s disease) - several days of high fevers FOLLOWED BY diffuse macular rash

Question 12

Timeline of Fifth disease

Answer 12

1. mild fever, headache, and runny nose
2. slapped cheek rash
3. lacy body rash

Question 13

How is HHV-8 spread?

Answer 13

Sexual contact leads to Kaposi’s sarcoma.

Question 14

What are the atypical lymphocytes seen in EBV blood smear?

Answer 14

Not infected B-cells, but rather reactive T-cells.

Question 15

How does acyclovir work?

Answer 15

Nucleoside analog w/ affinity for viral DNA polymerase.

Question 16

Which are the only dsRNA viruses?

Answer 16

Reoviruses (including rotavirus)

Question 17

1 cause of infantile gastroenteritis in the world?

Answer 17

Rotavirus (ROTA = Right Out The Anus)