Bacteriology 3

Question 0

What cancers can H. pylori increase the risk of?

Answer 0

gastric adenocarcinoma and lymphoma

Question 1

Which non-lactose fermenting, Gram (-) rod should you not use Abx with?

Answer 1

Salmonella

Question 2

Tx for H. pylori

Answer 2

Triple therapy

1. PPI (e.g. Omeprazole)
2. Clarithromycin
3. Amoxicillin or metronidazole

Question 3

How do macrolides work? Provide an example.

Answer 3

Inhibit protein synthesis by inhibiting peptidyl transferase and ribosomal translocation (50s). Azithromycin, clarithromycin, erythromycin.

Question 4

A surfer returns from a trip to St. Kitts complaining of flu-like Sx. He shouts when you turn on the light. Skin looks yellow, and his eyes look red like he’s been smoking too much pot. What’s he got?

Answer 4

Leptospirosis

Question 5

What would we call it if our surfer’s kidneys began to dysfunction? What are the other aspects of this syndrome?

Answer 5

Weil’s disease (icterohemorrhagic leptospirosis): jaundice, azotemia, fever, hemorrhage, and anemia.

Question 6

What other bacteria is carried by the Ixodes tick? What disease does it look like?

Answer 6

Babesia - Sx like malaria

Question 7

2 causes of chronic infective arthritis

Answer 7

TB and Borrelia

Question 8

BAKE a key Lyme pie

Answer 8

Bilateral Bell's palsy
Arthritis
Kardiac block (AV node)
Erythema migrans
(note: Sx appear in opposite order, except that neurologic Sx go 2nd w/ AV block)

Question 9

Tx for Lyme disease

Answer 9

doxycycline and ceftriaxone