Viral Lymphoproliferative Disorders and PTLD

Question 1

Hydroa Vaccineforme-like Lymphoma

Answer 1

Blue book p278-280

UV-inducible skin eruptions common.

Question 2

The incidence of PTLD is higher in patients who are ___ for EBV at the time of transplantation.

Answer 2

The incidence of PTLD is higher in patients who are seronegative for EBV at the time of transplantation.

Question 3

In solid organ transplant, PTLD is __ in origin.

In allogeneic HSCT, PTLD is __ in origin.

Answer 3

In solid organ transplant, PTLD is host in origin.

In allogeneic HSCT, PTLD is donor in origin.

Question 4

Most cases of PTLD are associated with ___

Answer 4

Most cases of PTLD are associated with Epstein Barr virus

However, they can be either T or B cell PTLD.

Question 5

Characteristics of PTLD cells

Answer 5

May be either T or B, or plasmacytic, and have a wide variety of morphologies.

They will usually be EBV+, but may be monoclonal or polyclonal.

Disease rarely involves the bone marrow or peripheral blood.