Viral infections of skin and soft tissue II

Question 1

What type of lesion spread is seen in smallpox?

Answer 1

Centrifugal - mostly on face and extremities

Question 2

What are the features of the smallpox lesion?

Answer 2

Pustular / scabbing, firm to the touch

Question 3

What family does variola virus belong to?

Answer 3

Poxviridae

Question 4

What is the variola virus genome?

Answer 4

Large dsDNA

Question 5

Where does variola virus replicate?

Answer 5

Cytoplasm

Question 6

What virus is responsible for smallpox?

Answer 6

Variola virus

Question 7

What comprises the smallpox vaccine?

Answer 7

Live strain of a vaccinia virus (different poxviridae family member)

Question 8

How can smallpox be differentiated from chickenpox?

Answer 8

Smallpox lesions develop on hands and feet and are synchronous

Question 9

What are the 3 Cs associated with measles?

Answer 9

Cough, coryza, conjunctivitis

Question 10

What sign is pathognomonic for measles?

Answer 10

Koplik’s spots - small white spots with red borders opposite molars on oral mucosa

Question 11

How is the measles rash described?

Answer 11

Maculopapular, beginning at the hairline and spready downward

Question 12

What family does the measles virus belong to?

Answer 12

Paramyxoviridae

Question 13

What is the measles virus genome?

Answer 13

ssRNA

Question 14

Is the measles virus enveloped or non-enveloped?

Answer 14

Enveloped

Question 15

Which gene is important for fusion of measles virus?

Answer 15

F gene

Question 16

Which protein is important for attachment of measles virus?

Answer 16

HA protein

Question 17

What percentage of measles cases involve complications?

Answer 17

30%

Question 18

What type of vaccine is the measles vaccine?

Answer 18

Live attenuated

Question 19

When is the measles vaccine recommended?

Answer 19

12-15 months, then at 4-6 years

Question 20

How is the German measles rash described?

Answer 20

Maculopapular, appearing first on face then spreading downward - does not coalesce

Question 21

Which virus is responsible for German measles?

Answer 21

Rubella virus

Question 22

What are the symptoms of congenital rubella syndrome?

Answer 22

Deafness, cataracts, congenital glaucoma, congenital heart disease, pigmentary retinopathy, purpura, hepatosplenomegaly

Question 23

What family does the rubella virus belong to?

Answer 23

Togavirus

Question 24

Is the rubella virus enveloped or non-enveloped?

Answer 24

Enveloped

Question 25

What is the rubella virus genome?

Answer 25

RNA

Question 26

What type of vaccine is the rubella vaccine?

Answer 26

Live attenuated

Question 27

What are the symptoms of fifth disease / erythema infectiosum?

Answer 27

Fever, characteristic rash beginning on cheeks

Question 28

What virus is responsible for fifth disease?

Answer 28

Parvoviridae

Question 29

What is the fifth disease genome?

Answer 29

ssDNA

Question 30

Where does B19 parvovirus grow?

Answer 30

Exclusively in mitotically active cells

Question 31

What virus is responsible for fifth disease?

Answer 31

B19 parvovirus

Question 32

Where does B19 parvovirus live within the body?

Answer 32

Hematopoietic cells in bone marrow

Question 33

What are disease manifestations of B19 parvovirus other than fifth disease?

Answer 33

Aplastic crisis, arthralgia and arthritis, pregnancy complications

Question 34

What virus is responsible for roseola infantum?

Answer 34

Human herpes virus 6 (HHV-6)

Question 35

What are the clinical symptoms of roseola infantum?

Answer 35

Maculopapular rash following fever, lasts 24-48 hours

Question 36

What is the genome of HHV-6?

Answer 36

dsDNA

Question 37

Is HHV-6 enveloped or non-enveloped?

Answer 37

Enveloped

Question 38

Where does HHV-6 replicate?

Answer 38

T cells, B cells, oral pharynx

Question 39

Where does HHV-6 maintain latency?

Answer 39

T cells

Question 40

When does HHV-7 infection occur?

Answer 40

Following HHV-6 infection