Bacterial infections of the CNS II Flashcards

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1
Q

What is the gram staining for S. agalactiae?

A

Gram positive

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2
Q

What is the shape of S. agalactiae?

A

Long chains

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3
Q

What is the catalase test for S. agalactiae?

A

Negative

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4
Q

What is the hemolysis pattern for S. agalactiae?

A

Beta

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5
Q

What is the most common cause of sepsis and meningitis in neonates less than 2 months of age?

A

S. agalactiae

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6
Q

What are the virulence factors for S. agalactiae?

A

Polysaccharide capsule, absence of maternal antibodies

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7
Q

What is the risk of GBS transmission from from mother to child during birth?

A

2%

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8
Q

What is the treatment for GBS infection?

A

Penicillin

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9
Q

What is the prevention for GBS?

A
  1. Universal screening of pregnant women 2. NO vaccine
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10
Q

What is the gram stain for HIB?

A

Gram negative

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11
Q

What does HIB require for growth?

A

Hemin (X) and NAD (V) factors

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12
Q

What do the non-encapsulated strains of HIB cause?

A

Pinkeye, otitis media, sinusitis

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13
Q

What do the encapsulated strains of HIB cause?

A

Meningitis, epiglottitis

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14
Q

Which meningitis-causing pathogen is associated with hearing loss?

A

HIB

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15
Q

What is the diagnosis for HIB?

A

Gram stain, latex agglutination

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16
Q

When is HIB vaccination initiated?

A

2 months of age

17
Q

What is the gram stain of clostridium tetani?

A

Gram positive

18
Q

Does clostridium tetani form spores?

A

Yes (“drumstick” appearance)

19
Q

What type of toxin is the tetanus toxin?

A

A-B toxin

20
Q

What is the pathogenesis of the tetanus toxin?

A
  1. B binds to motor neurons 2. Toxin internalized and transported to spinal cord 3. Inactivates release of inhibitory neurotransmitters 4. SPASTIC PARALYSIS
21
Q

What is the treatment for tetanus?

A
  1. Passive - administer Ig 2. Active - vaccinate with tetanus toxoid
22
Q

What is the goal for tetanus treatment?

A

Remove any unbound toxin (binding is irreversible)

23
Q

When is tetanus vaccination initiated?

A

2 months of age (boosters every 10 years)

24
Q

What is the gram stain for clostridium botulinum?

A

Gram positive

25
Q

What is the pathogenesis of botulism toxin?

A
  1. A-B toxin 2. B binds and A enters motor neurons 3. A blocks release of Ach 4. Blocks stimulation - FLACCID PARALYSIS
26
Q

What is the gram stain for listeria monocytogenes?

A

Gram positive

27
Q

What is the shape of listeria monocytogenes?

A

Motile rod (coccobacillus)

28
Q

S. aureus meningitis typically follows what condition?

A

Bacteremia