viral hepatitis part 2 W5 Flashcards
hepatitis C structure and family?
enveloped ss+ve RNA flavivirus
HCV incubation time?
15-160 days
HCV primarily affects?
adults
HCV seasonality?
no seasonality
transmission of HCV?
parenteral transmission. ?sexual
HCV acute and chronic phase?
acute phase often completely asymptomatic
chronic infection in 70-90% of cases
chronic infection associated with hepatocellular cancer
HCV fatality
up to 1% fatality rate in icteric cases
HCV vaccine?
no vaccine avaliable
HCV treatment
interferon alpha with ribavirin or direct acting antivirals such as protease inhibitors and/or polymerase inhibitors
HCV course of infection?
anti-HCV antibodies (indicates recent/past infection)
HCV antigen (active infection)
HCV PCR (determines if active)
IL28B genotype (determines susceptibility to antiviral therapy)
hepatitis D structure?
enveloped circular ss-ve RNA
hepatitis D features
defective virus needing HBV for replication
co-infection with HBV (severe acute disease, low risk of chronicity)
super-infection on chronic HBV infection (chronic HDV infection, high risk of severe chronic liver disease)
HDV vaccination?
HBV vaccination provides indirect protection against HDV
hepatitis E virus structure and family?
non-enveloped ss+ve RNA hepevirus
HEV transmission
faecal-oral
