Viral Hepatitis

Question 1

Only human hepatitis virus that is a DNA virus

Answer 1

Hepatitis B

• hepadnaviridae
• uses reverse transcriptase enzyme

Question 2

HBV serology

first detectable marker

Answer 2

HBs antigen (HBsAg)

Question 3

HBV serology

QUALITATIVE marker for high infectivity/replication

Answer 3

HBe antigen (HBeAg)

Question 4

HBV serology

QUANTITATIVE marker for high infectivity/replication

Answer 4

HBV DNA

Question 5

HBV serology

first antibody to rise

Answer 5

anti-HBc antibody

Question 6

HBV serology

positive during window period

Answer 6

IgM anti-HBc antibody

Question 7

HBV serology

protective antibody and the only marker to appear after immunization

Answer 7

anti-HBs antibody

Question 8

Vasculitic syndrome associated w/ HBV infection

Answer 8

polyarteritis nodosa (PAN)

Question 9

MC symptom in hepatitis C

Answer 9

fatigue

Question 10

MC risk factor for hepatitis C

Answer 10

injection drug use

Question 11

The MC genotype of hepatitis C worldwide

Answer 11

genotype I

Question 12

Gold standard for establishing a diagnosis of hepatitis C

Answer 12

HCV RNA

Question 13

Defective RNA virus that coinfects w/ and requires helper function of HBV

Answer 13

hepatitis D virus

Question 14

Distinguishing serologic feature of chronic hepatitis D

Answer 14

presence of antibodies to liver-kidney microsomes (anti-LKM3)

Question 15

Hepatitis infection associated w/ essential mixed cryoglobulinemia

Answer 15

HCV

Question 16

Viral Taxonomy

Answer 16

Hepa A - picoRNAviridae
Hepa B - hepaDNAviridae
Hepa C - Flaviridae
Hepa D - Caliciviridae