venous thrombosis Flashcards
3 layers of the artery? tunica…
TI Tunica Interna
TM Tunica Media
TE Tunica Externa
what chemical is responsible for the aggregation of platelets?
thromboxane A2
what drug is given to treat arterial platelet rich thrombus?
aspirin (prevents production of TXA2 by inhibiting COX)
what is the difference between an arterial clot and a venous clot
arterial is high pressure and is platelet rich clot, venous is low pressure and is a fibrin rich clot
what is virschows triad?
stasis
vessel wall
hypercoagulability
treatment of venous clot?
warfarin, heparin
symptoms of pulmonary embolism?
pleuritic chest pain, collapse
Risk factors for venous thromboembolism?
Age Marked obesity Pregnancy Puerperium Oestrogen therapy Previous DVT/PE Trauma/Surgery Malignancy Paralysis Infection Thrombophilia (eg factor 5 leydig)
what states are associated with raised tissue factor, factor 8 and raised vwf?
malignancy, trauma, infection, pregnancy, age
thrombophilia likely to predispose to ?
thrombus (decreased anti coagulant activity)
proten c and protein s deficiencies are examples of what?
thrombophilias (thrombo for sure)
consider hereditary thrombophilia screening if?
venous thrombosis in under 45 Recurrent venous thrombosis Unusual venous thrombosis Family history of venous thrombosis Family history of thrombophilia
if recurrent thrombotic events, how do you treat?
long term anti coagulation
how do you treat anti phospholipid syndrome?
because you get arterial and venous thrombosis - treat with aspirin (arteries) and veins (warfarin)
