arterial thrombosis and anti platelet drugs

Question 1

what is atherosclerosis?

Answer 1

not the same as arterial thrombosis
damage to the endothelium
recruitment of foamy macrophages rich in cholesterol
forms plaques rich in cholesterol

Question 2

stable atherosclerotic plaques?

Answer 2

hyalinised and calcified

Question 3

unstable plaques

Answer 3

plaques rupture, platelets are recruited and cause acute thrombosis

Question 4

plaque ruptures are more likely in high pressure environment of arteries

Answer 4

y

Question 5

platelets formed in the bone marrow by?

Answer 5

budding from megakaryocytes

Question 6

what chemicals do platelets secrete

Answer 6

ADP, TXA A2

Question 7

leads to aggregation of platelets at the site of injury

Answer 7

y

Question 8

aspirin works by ?

Answer 8

inhibiting cycloo oxygenase w which is necessary to produce TXA2

Question 9

side effects?

Answer 9

bleeding, blockage of production of prostaglandins, GI ulceration and bronchospasm

Question 10

clopidogrel

Answer 10

ADP receptor antagonists

Question 11

dipyridamole

Answer 11

phosphodiesterase inhibitor - reduces production of camp, which is a second messenger in platelet activation