arterial thrombosis and anti platelet drugs Flashcards

1
Q

what is atherosclerosis?

A

not the same as arterial thrombosis
damage to the endothelium
recruitment of foamy macrophages rich in cholesterol
forms plaques rich in cholesterol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

stable atherosclerotic plaques?

A

hyalinised and calcified

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

unstable plaques

A

plaques rupture, platelets are recruited and cause acute thrombosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

plaque ruptures are more likely in high pressure environment of arteries

A

y

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

platelets formed in the bone marrow by?

A

budding from megakaryocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what chemicals do platelets secrete

A

ADP, TXA A2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

leads to aggregation of platelets at the site of injury

A

y

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

aspirin works by ?

A

inhibiting cycloo oxygenase w which is necessary to produce TXA2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

side effects?

A

bleeding, blockage of production of prostaglandins, GI ulceration and bronchospasm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

clopidogrel

A

ADP receptor antagonists

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

dipyridamole

A

phosphodiesterase inhibitor - reduces production of camp, which is a second messenger in platelet activation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly