introduction lecture

Question 1

3 types of blood cell

Answer 1

red white platelet

Question 2

types of white blood cells?

Answer 2

monocytes, neutrophil, eosinophil, basophil, lymphocyte, NK cell

Question 3

what is haemopoeisis?

Answer 3

production of blood cells

Question 4

derived from?

Answer 4

pluripotent stem cells

Question 5

sites of haemopoeisis in embryo?

Answer 5

yolk sac then liver

3rd to 7th month spleen

Question 6

at birth

Answer 6

mostly bone marrow, liver and spleen when needed

Question 7

from birth to maturity?

Answer 7

number of active sites in bone marrow decreases, but retain ability for haematopoesis

Question 8

adult?

Answer 8

bone marrow of skull, ribs, sternum, pelvis, proximal ends of femur

Question 9

haematopoetic stem cell generates wide array of?

Answer 9

different cell types

Question 10

what has to happen to a stem cell to make blood

Answer 10

proliferaton

and differentiation

Question 11

neutrophili progression?

Answer 11

myeloblast, promyelocyte, myelocyte, metamyelocyte, neutrophils (my prog, my meta)

Question 12

erythropoeisis

Answer 12

pro ba po o r - mature red blood cell

Question 13

granulocytes? (3)

Answer 13

basophils, eosinophils, neutrophils

Question 14

why are they easily visible on light microscopy?

Answer 14

they contain granules

Question 15

neutrophils - nucleus? granules?

Answer 15

segmented nucleus, neutral staining granules

Question 16

short life in circulation. phagocytose invaders, kill with granule contents and die in the process

Answer 16

attract other cells, increased body stress - infection trauma, infarction

Question 17

Eosinophils - nucleus?

Answer 17

bilobed

Question 18

granules?

Answer 18

bright orange/red

Question 19

what is their function?

Answer 19

fight parasitic infections, involved in hypersensitivity, often elevated in patients with allergic conditions

Question 20

bilobed granulocyte with orange/red granules?

Answer 20

eosinophil

Question 21

basophils - infrequent in circulation. granules?

Answer 21

large deep purple granules obscuring the nucleus

Question 22

what do its granules contain?

Answer 22

histamine

Question 23

what are they a circulating version of?

Answer 23

mast cell

Question 24

what do they mediate?

Answer 24

hypersensitivity reactions

Question 25

FcReceptors bind IgE

Answer 25

y

Question 26

purple/blue black granules overlying the nucleus?

Answer 26

basophil

Question 27

monocytes - nucleus?

Answer 27

large single nucleus

Question 28

granules?

Answer 28

faintly staining, often vacuolated

Question 29

function?

Answer 29

circulate for a week and enter tissues to become macrophages

Question 30

phagocytose invaders

Answer 30

attract other cells.

Question 31

longevity compared to neutrophils?

Answer 31

live longer than neutrophils

Question 32

lymphocytes?

Answer 32

mature - small with a condensed nucleus and rim of cytoplasm

Question 33

activated?

Answer 33

large with plentiful blue cytoplasm extending round neighbouring cells . nucleus more open structure

Question 34

types of white blood cell?

Answer 34

basophils, eosinophils, neutrophils,

Question 35

which cells are have a segmented nucleus, phagocytose cells, release granules and die in process. These are usually first to rise in infection

Answer 35

neutrophils

Question 36

usually bi lobed? bright orange granules?

Answer 36

eosinophils

Question 37

large deep purple granules obscuring nucleus?

Answer 37

basophils

Question 38

Large single nucleus
Faintly staining granules
Often vacuolated
Circulate for a week and enter tissues to become macrophages

Answer 38

monocytes