introduction lecture Flashcards

1
Q

3 types of blood cell

A

red white platelet

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2
Q

types of white blood cells?

A

monocytes, neutrophil, eosinophil, basophil, lymphocyte, NK cell

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3
Q

what is haemopoeisis?

A

production of blood cells

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4
Q

derived from?

A

pluripotent stem cells

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5
Q

sites of haemopoeisis in embryo?

A

yolk sac then liver

3rd to 7th month spleen

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6
Q

at birth

A

mostly bone marrow, liver and spleen when needed

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7
Q

from birth to maturity?

A

number of active sites in bone marrow decreases, but retain ability for haematopoesis

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8
Q

adult?

A

bone marrow of skull, ribs, sternum, pelvis, proximal ends of femur

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9
Q

haematopoetic stem cell generates wide array of?

A

different cell types

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10
Q

what has to happen to a stem cell to make blood

A

proliferaton

and differentiation

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11
Q

neutrophili progression?

A

myeloblast, promyelocyte, myelocyte, metamyelocyte, neutrophils (my prog, my meta)

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12
Q

erythropoeisis

A

pro ba po o r - mature red blood cell

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13
Q

granulocytes? (3)

A

basophils, eosinophils, neutrophils

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14
Q

why are they easily visible on light microscopy?

A

they contain granules

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15
Q

neutrophils - nucleus? granules?

A

segmented nucleus, neutral staining granules

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16
Q

short life in circulation. phagocytose invaders, kill with granule contents and die in the process

A

attract other cells, increased body stress - infection trauma, infarction

17
Q

Eosinophils - nucleus?

18
Q

granules?

A

bright orange/red

19
Q

what is their function?

A

fight parasitic infections, involved in hypersensitivity, often elevated in patients with allergic conditions

20
Q

bilobed granulocyte with orange/red granules?

A

eosinophil

21
Q

basophils - infrequent in circulation. granules?

A

large deep purple granules obscuring the nucleus

22
Q

what do its granules contain?

23
Q

what are they a circulating version of?

24
Q

what do they mediate?

A

hypersensitivity reactions

25
FcReceptors bind IgE
y
26
purple/blue black granules overlying the nucleus?
basophil
27
monocytes - nucleus?
large single nucleus
28
granules?
faintly staining, often vacuolated
29
function?
circulate for a week and enter tissues to become macrophages
30
phagocytose invaders
attract other cells.
31
longevity compared to neutrophils?
live longer than neutrophils
32
lymphocytes?
mature - small with a condensed nucleus and rim of cytoplasm
33
activated?
large with plentiful blue cytoplasm extending round neighbouring cells . nucleus more open structure
34
types of white blood cell?
basophils, eosinophils, neutrophils,
35
which cells are have a segmented nucleus, phagocytose cells, release granules and die in process. These are usually first to rise in infection
neutrophils
36
usually bi lobed? bright orange granules?
eosinophils
37
large deep purple granules obscuring nucleus?
basophils
38
Large single nucleus Faintly staining granules Often vacuolated Circulate for a week and enter tissues to become macrophages
monocytes