trnasfusion Flashcards
4 bacteria that can cause bacterial infection?
staph, strep, serratia, salmonella
can be contamiinated with pseudomonas yersinia
pyerself
risk of HIV infection?
small
who gets circa overload?
old people - those with CCF are at risk. causes pulmonary oedema. reduce transfusion rate
what are urticarial reactions?
mast cell IgE response to infused plasma proteins
what would you give?
consider anti histamines
rapid temperature increase, antibodies to contaminating white cells. release of cytokines and vasoactive substances during storage
febrile non haemolytic transfusion reaction
which antibodies may be detectable?
HLA
what exactly is Febrile non-hemolytic transfusion reaction?
Febrile non-hemolytic transfusion reaction is a type of transfusion reaction that is associated with fever but not directly with hemolysis. It is most commonly caused by antibodies directed against donor leukocytes and HLA antigens.
what is the management?
STOP REACTION, can prevent with anti pyrites
transfusion reaction 5-10 days after blood transfusion?
delayed haemolytic transfusion reaction
why is serum HAPTOGLOBIN low in a transfusion reaction?
it binds to free haemoglobin released from the RBCs
transfusion reaction steps
IgM, complement, release of c3a and c5a, mac, rupture of transfused cells, coagulation (thromboplastin material from haemolysed cells), activates coagulation mechanism, disseminated intravascular dissemination)
why do you get coagulation?
material from destroyed cells
3 interlinked systems in transfusion reaction?
compliment system, coaguation system, kinin system
