iron in health disease]] Flashcards
iron important in electron transport e.g.?
mitochondria production of ATP
ferric ?
fe3
ferrous
fe2
iron present in ? (3)
haemoglobin, myoglobin, enzymes eg cytochroms
why is iron dangerous?
it induces oxidative stress
assessment of iron status
functional - haemoglobin
transport (% saturation with transferrin)
storage (ferritin)
what transports iron from donor tissues to tissues expressing receptors ?
transferrin
ferritin - large intracellular protein - stores up to ?
4000 iro arims
tiny amount of serum ferritin reflects intracellular ferritin synthesis in response to iron - indirect measure of storage iron
y
how is iron absorption regulated?
intraluminal factors - solubility or iron, reduction of ferric to ferrous.
mucosal factors - DMT 1 and ferroportin at mucosal surface
hepcidin - major negative regulator of iron uptake.
where is hepcidin produced?
liver
what is it produced in response to?
iron load and inflammation
what facilitates iron export from the enterocyte?
ferroportin
what is iron passed on to to be transported elsewhere?
transferrin
what does hepcidin do?
down regulates ferroportin
normal amount of iron in the body?
4g
lack of iron?
angular stomatitis, koilonychia, skin changes
iron deficiency can be confirmed by?
combination of anaemia and low storage iron (ferritin)