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haematology > haemostasis > Flashcards

haemostasis Flashcards

1
Q

primary haemostasis?

A

formation of platelet plug

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2
Q

2y haemostasis?

A

fibrin clot

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3
Q

platelet lifespan?

A

7 - 10 days

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4
Q

endothelial wall damage exposes?

A

collagen and releases von willebrand factor

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5
Q

platelet adhesion at site of injury

A

secretion of various chemicals by platelets which leads to aggregation

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6
Q

failure of platelet plug formation, causes?

A

vascular, platelets (reduced number - thrombocytopenia)
reduced function
von Hillebrand factor

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7
Q

consequences of failure of platelet plug formation?

A

EASY BRUISING epistaxes, gastrointestinal, conjunctival, menorrhagia

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8
Q

can also get inter cranial haemorrhage and retinal haemorrhage

A

y

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9
Q

secondary clot formation - what 2 things involved in initiation?

A

TF and VIIa

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10
Q

propagation?

A

v an xa

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11
Q

amplification?

A

thrombin -> VIII/IXa ->V/Xa

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12
Q

failure of fibrin clot either?

A

hereditary - haemophilia - single cutting factor deficiency

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13
Q

multiple clotting factor deficiencies?

A

DIC

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14
Q

increased fibrinolysis?

A

usually part of complex coagulopathy

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15
Q

what breaks down fibrin to FDPs?

A

plamin

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16
Q

what activates plasminogen?

A

tissue plasminogen activator

17
Q

haemophilia 1 is absence of VIII

A

haemophilia 2 is absence of factor IX

18
Q

what kind of inhibitor is anti thrombin III?

A

serine protease inhibitor

19
Q

what does thrombin bind to which activities protein c and protein s, which then inhibit v/xa and viii/ixa

A

thrombomodulin

20
Q

what is thrombophilia?

A

lOw anticO Deficiency of naturally occuring anticoagulants may be hereditary

21
Q

increased tendency to form venous thrombosis

A

y

22
Q

most common thrombophilia?

A

factor 5 leydig

23
Q

platelets made from?

A

megakaryocytes

24
Q

factor 5 leydig. causes an increase in ?

A

clotting. factor 5 leydig is a mutant variant of factor 5

haematology (20 decks)

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