Vacomycin

Question 1

chemical nature of vancomycin

Answer 1

tricyclic glycopeptide

Question 2

use of vancomycin

Answer 2

MRSA
MRSE(staph epidermidis)
clostridium difficile
for individuals having prostheitic heart valve
pts undergoing surgery

Question 3

Is tdm conducted for vancomycin

Answer 3

Yes (Trough levels are measured)

Question 4

ROUTE OF ADM

Answer 4

iv infusion
oral only for c difficile(antibiotic assoc colitis treatment)
poorly absorbed after oral adm

Question 5

mechanism of action

Answer 5

Prevent transglycosylation step in peptidoglycan polymerization.(inhibits cell wall synthesis)

Question 6

adrs of vancomycin

Answer 6

1) fever
2) phlebitis in the infusion site
3) Flushing (red man syndrome)
4) Ototoxicity & nephrotoxicity when comb. With A.G.

Question 7

is vancomycin used in combination? if yes than what are those combinations?

Answer 7

Vancomycin + A.G. (synergism) → ttt of enterococcal endocarditis (E.E)
Vancomycin + Ceftriaxone → Meningitis.

Question 8

what is used for vancomycin resistant organisms

Answer 8

Quinopristin/ daflopristin &linezolid