Clindamycin Flashcards
1
Q
Mechanism of Action
A
irreversibly binds to 50S subunit
inhibits translocation steps of protein synthesis
2
Q
spectrum of clindamycin
A
Anaerobes and G +ve
3
Q
resistance
A
efflux mechanism
dec affinity to 5oS ribosome
4
Q
ADR
A
skin rash
pseudomemberanous colitis(can be fatal)— treated with vancomycin+metronidazole)
5
Q
route of adm?
A
IV and oral
6
Q
excretion
A
extended oxidative metabolism which converts it into active and inactive products
so excreted in bile and urine
