Fluoroquinolones

Question 1

mechanism of action?

Answer 1

inhibit the synthesis of DNA gyrase and topoisomerase IV

Question 2

what class of drugs do fluoroquinones fall under

Answer 2

DNA synthesis inhibitors

Question 3

what drugs are included in fluoroquinolones

Answer 3

ciprofloxacin
levofloxacin
moxifloxacin
gemifloxacin
ofloxacin
balefloxacin

Question 4

route of administration

Answer 4

all can be given either Oral and IV
Cipro and ofloxacin can be given as Otic formulations
Moxifloxacin can be given as opthalmic forumulation

Question 5

broad or narrow spectrum

Answer 5

broad

Question 6

bacteriostatic or bactericidal

Answer 6

bactericidal

Question 7

spectrum of FQ’s

Answer 7

Gram -ve
against certain mycobacteria(treats TB)

Question 8

resistance`

Answer 8

efflux pump
mutation on gene that codes for topoisomerase

Question 9

what drugs are included in older fluoroquinolones

Answer 9

Ciprofloxacin

Question 10

drawback of older FQ’s

Answer 10

less active against gram+

Question 11

what drugs are included in new fq’s

Answer 11

levo
moxi
gemi

Question 12

what is another name for new generation fq’s

Answer 12

respiratory fq’s

Question 13

which type of pneumonia are new fq’s used for

Answer 13

community acquired pneumonia

Question 14

why arent new fq’s used for hospital acquired pneumonia

Answer 14

less effective against pseudomonas aeruginosa

Question 15

what is the spectrum of moxi

Answer 15

gram +ve and anaerobes
less active against pseudomonas aeruginosa

Question 16

levofloxacin uses

Answer 16

C A P — first line
p aeruginosa
complicated UTI

Question 17

which drug is the DOC for anthrax

Answer 17

Cipro

Question 18

uses of cipro

Answer 18

anthrax
acute diarrheal illness
uti
gonorrhea
most potent quinolone against p. aeruginosa

Question 19

metabolism of fq

Answer 19

liver— via cyp 450
also inhibit cyp 450

Question 20

excretion

Answer 20

renally

Question 21

which fq is only given IV

Answer 21

trovafloxacin

Question 22

fq with the longest doa

Answer 22

levo and moxi

Question 23

side effecst

Answer 23

phototoxic
tendenitis
cartilage damage in children
agitation
dec threshold for seizures
arrythmia

Question 24

contraindication

Answer 24

pregnancy
growing children
athletes

Question 25

most fq’s are not effective against

Answer 25

MRSA

Question 26

fq,s shouldnt be taken with

Answer 26

iron
zinc
calcium— due to chelation and dec absorption

Question 27

fq are used in the empiric treatment of what disease

Answer 27

pyelonephritis