Fluoroquinolones Flashcards
mechanism of action?
inhibit the synthesis of DNA gyrase and topoisomerase IV
what class of drugs do fluoroquinones fall under
DNA synthesis inhibitors
what drugs are included in fluoroquinolones
ciprofloxacin
levofloxacin
moxifloxacin
gemifloxacin
ofloxacin
balefloxacin
route of administration
all can be given either Oral and IV
Cipro and ofloxacin can be given as Otic formulations
Moxifloxacin can be given as opthalmic forumulation
broad or narrow spectrum
broad
bacteriostatic or bactericidal
bactericidal
spectrum of FQ’s
Gram -ve
against certain mycobacteria(treats TB)
resistance`
efflux pump
mutation on gene that codes for topoisomerase
what drugs are included in older fluoroquinolones
Ciprofloxacin
drawback of older FQ’s
less active against gram+
what drugs are included in new fq’s
levo
moxi
gemi
what is another name for new generation fq’s
respiratory fq’s
which type of pneumonia are new fq’s used for
community acquired pneumonia
why arent new fq’s used for hospital acquired pneumonia
less effective against pseudomonas aeruginosa
what is the spectrum of moxi
gram +ve and anaerobes
less active against pseudomonas aeruginosa
levofloxacin uses
C A P — first line
p aeruginosa
complicated UTI
which drug is the DOC for anthrax
Cipro
uses of cipro
anthrax
acute diarrheal illness
uti
gonorrhea
most potent quinolone against p. aeruginosa
metabolism of fq
liver— via cyp 450
also inhibit cyp 450
excretion
renally
which fq is only given IV
trovafloxacin
fq with the longest doa
levo and moxi
side effecst
phototoxic
tendenitis
cartilage damage in children
agitation
dec threshold for seizures
arrythmia
contraindication
pregnancy
growing children
athletes
most fq’s are not effective against
MRSA
fq,s shouldnt be taken with
iron
zinc
calcium— due to chelation and dec absorption
fq are used in the empiric treatment of what disease
pyelonephritis
