CEPHALOSPORINS Flashcards
Cephalosporins are closely related to which antibiotics
penicillins
how are cephalosporins produced
by the addition of 7 amino cephalosporanic acid to the penicillins
first gen cephalosporins act as
pen G substitutes
are the 1st gen cephalosporins resistant to staph penicillanase
yes thats why they act on MSSA
WHAT OTHER ORGANISMS DO 1ST GEN WORKS ON
PROTEUS MIRABILIS
E coli
K Pneumonia
P EC K
2ND GEN CEPHALOSPORINS HAVE ACTIVITY AGAINST WHAT MICRO ORGANISMS
P EC K
and also on some other gram - organsims that are
H influenza
Enterobacter aerogenes
Neisserha
making the whole acronym to HEN P EC K
is 2nd gen cephalosporins stronger against gram + or gram -
gram -
which cephalosporins drugs are commercially available to treat against B fragilis
Cephamycin
Cefoxitin
3rd gen activity against gram + and gram -
↓ G+ve, ↑G-ve
drug of choice in Meningitis
Ceftriaxone(3rd gen)
what is ceftazidine(3rd gen) used for
it is used for Pseudomonas aeruginosa
what is ceftazidime(3rd gen) used for
it is used for Pseudomonas aeruginosa
4th gen cephalosporins are
Wide spectrum
route of adm of 4th gen
parentral
what is the drug that is included in 4th gen
Cefepime
drugs that are included in 2nd gen
Cefoxitin
cephamycin
cefaclor
drugs that are included in 1st gen
Cefadroxil
Cefazolin
Cephalexin
drugs that are included in 3rd gen
ceftriaxone
ceftazidime
cefotaxime
adrs of cephalosporins
1) hypersensitivity especially with patients sensitive to penicillins.
2) Disulfiram like effects
which pts shouldnt receive cephalosporins
steven johnsons syndrome
toxic epidermal necrosis
penicillin allergy(avoided or used with caution)
elimination of cephalosporins
via kidney
uses of cephalosporins
Uses: as penicillins.
**Ceftriaxone, Cefotaxime →CSF→ Meningitis caused by H. influenza.
Ceftriaxone is used in renal failure.
**Cefazolin→ prior to surgery, penetrates bone
