Quinopristin/dalfopristin

Question 1

what is this antibiotic a mixture of?

Answer 1

two streptogramins in 30/70 ratio`

Question 2

due to significant adrs what is this class reserved for the treatment of

Answer 2

VRE in the absence of other therapeutic options

Question 3

moa

Answer 3

each component of this combo binds to a seperate site at 50S bacterial ribosome

Question 4

spectrum

Answer 4

gram positive including those that are resistant to other antibiotics such as VRE

Question 5

resistance

Answer 5

enzymatic
plasmid assoc acetyltransferase inactivates dalfosporin

Question 6

route of adm

Answer 6

IV IN 5% DEXTROSE
UNSTABLE IN SALINE

Question 7

metabolism

Answer 7

by liver

Question 8

excretion

Answer 8

feces

Question 9

level IN csf

Answer 9

low

Question 10

adrs

Answer 10

1)Venous irritation.
2) Arthralgia & Myalgia.
3) Hyperbilirubinemia →↑ total bilirubin due to competing with antibiotic for excretion

Question 11

bacteriostatic or bactericidal?

Answer 11

bactericidal

Question 12

interactions

Answer 12

1) Inhibit cyp450(3A4).
2) Interacts with digoxin