MONOBACTAMS

Question 1

What is the only commercially available monobactam

Answer 1

Aztreonam

Question 2

which micro organisms is aztreonam active against

Answer 2

Only aerobic gram -ve rods
pseudomonas aeruginosa
Enterobacteriaceae
treat serious systemic infections caused by gram -ve path (pneumonia,meningitis, sepsis)
(Not ACTIVE AGAINST GRAM +VE)

Question 3

Route of adm

Answer 3

IV OR IM

Question 4

Excretion

Answer 4

renally(can accumulate in people with renal failure)

Question 5

adrs

Answer 5

Aztreonam is relatively nontoxic, but it may cause phlebitis, skin
rash and, occasionally, abnormal liver function tests

Question 6

why is it used for pts who are allergic to penicillin

Answer 6

This drug has a
low immunogenic potential, and it shows little cross-reactivity with antibodies
induced by other β-lactams.