carbapenems

Question 1

Carbapenems are synthetic β-lactam antibiotics that differ in structure
from the penicillins - how?

Answer 1

sulfur of thiazolidine ring is externalized and replaced with Carbon

Question 2

drugs in this class

Answer 2

imipenem
meropenem
ertapenem
doripenem

Question 3

why is imipenem used with cilastatin

Answer 3

Imipenem is compounded with cilastatin to protect it from metabolism
by renal dehydropeptidase

Question 4

imipenem resists hydrolysis by most β-lactamases, but not the

Answer 4

Metallo beta lactamase

Question 5

route of adm of carbapenems

Answer 5

IV

Question 6

excretion?

Answer 6

renally(glomerular filteration)

Question 7

what are the broadest spectrum Beta lactams

Answer 7

imipenem/cilastatin and meropenem

Question 8

why is imipenem alone harmful?

Answer 8

Imipenem undergoes cleavage by a dehydropeptidase found
in the brush border of the proximal renal tubule. This enzyme
forms an inactive metabolite that is potentially nephrotoxic.

Question 9

uses of carbapenems?

Answer 9

*Used as empiric therapy.
*Active# penicillinase producing G+ve, G-ve, anaerobes & p. aeruginosa.

Question 10

adrs of carbapenems

Answer 10

Imipenem/Cilastatin→ N, V, and diarrhea.
High doses→ seizures. (Not seen with Meropenem).