Trimethoprim

Question 1

what class does trimethoprim belongs to

Answer 1

dihydrofolate reductase inhibitor

Question 2

moa

Answer 2

The active form of folate is the tetrahydro derivative that is formed through reduction of dihydrofolic acid by dihydrofolate reductase. This enzymatic reaction is inhibited by trimethoprim, leading to a decreased availability of the tetrahydrofolate cofactors required for purine, pyrimidine, and amino acid synthesis.

Question 3

spectrum

Answer 3

similar to sulfamethoxazole but it is 20-50 times more potent

Question 4

uses

Answer 4

treatment of UTI and Prostatitis

Question 5

combos

Answer 5

trimethoprim + sulfamethoxazole—- pneumocystic jeruvici pneumonia, toxoplasmosis, nocardiosis

Question 6

what are the uses of other dihydrofolate reductase inhibitor

Answer 6

Pyrimethamine in parasitic infections & Methotrexate in cancer & R.A
pyrimethamine+ sulfadiazine is used in toxoplasmosis

Question 7

resistance

Answer 7

efflux pump
alteration of dihydrofolate reductase
dec permeability

Question 8

oral or iv

Answer 8

oral

Question 9

where in the body is the conc higher

Answer 9

prostatic and vaginal fluids

Question 10

excretion

Answer 10

renally 80% unchanged

Question 11

adrs

Answer 11

megaloblastic anemia
leukocytopenia
granulocytopenia
all of these can be treated with folinic acid

Question 12

adrs

Answer 12

megaloblastic anemia
leukocytopenia
granulocytopenia
all of these can be treated with folinic acid
also another adr that is Hyperkalemia