LINEZOLID Flashcards
1
Q
Chemistry of linezolid?
A
synthetic oxazolidinone
2
Q
main clinical use of linezolid?
A
drug resistant gram +ve orgasnisms
such as staph, strep and enterococci and corynebacterium and listeria
moderate activity against mycobacterium TB.
3
Q
bacteriostatic or bactericidal
A
bacteriostatic but bactericidal against strep
4
Q
moa of linezolid
A
binds to 23S RNA of 50S ribosomal subunit
5
Q
resistance
A
reduced binding at the receptor site
6
Q
route of adm
A
iv and oral
7
Q
any effect on cyp 450
A
no
8
Q
excretion
A
renal and non renal routes
9
Q
any dose adjustments?
A
no dose adjustments for renally or hepatically impaired pts
10
Q
adrs
A
1) Rash.
2) Thrombocytopenia if the drug is taken > 2 weeks.
3) GIT, nausea & diarrhea
4) serotonin syndrome if given large amounts of tyramine containing foods.
