chloramphenicol Flashcards
1
Q
spectrum of chloramphenicol
A
BROAD SPECTRUM
chlamydia, ricketsia, spirochetes and anaerobes
bacteriostatic but dep on dose can be bactericidal
2
Q
moa of chloramphenicol
A
reversible binding to 50S— inhibit synthesis at peptidyl transferase reaction
3
Q
resistance
A
enzymatic inactivation
4
Q
route of adm
A
IV
5
Q
metabolism
A
hepatic
6
Q
elimination
A
urine
7
Q
contraindication
A
released in breast milk so should be avoided in breast feeding mothers
8
Q
adrs
A
1) Anemia & Aplastic&hemolytic anemia.
2) Gray baby syndrome→ cyanosis & death.
9
Q
drug interactions
A
With Warfarin & phenytoin: → Chloramphenicol ↑ their conc
