Vaccines Flashcards
What is antigenic component of HBV vaccine?
HBsAG
How is HBV vaccine produced?
Recombinant DNA inserted into yeast
What is antigenic component of VZV vaccine?
live attenuated whole virus
How is VZV vaccine produced?
Oka strain of live virus grown in human fibroblasts- MRC5 cells
What is main difference between VZV (zoster) and Shingles vaccine?
Shingles vaccine (zostavax) for >70 years old
Live attenuated
It is >40x more potent, as older patients have immunosennescence
Shingrix vaccine in USA uses glycoprotein E. Not used in UK
Subunit vaccine
What is antigenic component of Mumps vaccine?
How is it produced?
Live attenuated whole virus
grown on chick embryo (not eggs)
Mumps vaccine - what strains are used?
Jeryl Lynn used in UK
Urabe 2nd most popular around world
Others -
Hoshino, Leningrad-3, L-Zagreb, Miyahara, Torii,
NK M-46, S-12 and RIT 4385
What is antigenic component of Rubella vaccine?
How is it produced?
Live attenuated whole virus
grown using human cells
Measles vaccine - what strains are used?
Edmonston-Enders strain used in UK
Rubella vaccine - what strains are used?
Wistar RA 27/3 strain
Other Japanese/ Chinese strains exist
List different types of SARS-CoV-2 vaccine antigenic components
RNA
mRNA
Spike protein
Matrix protein
How does HBV fit into routine vaccination schedule?
three doses total
8/ 12/ 16 weeks of age
Baby born to HBV infected mother.
How does this affect vaccination schedule?
six doses total
birth 4 weeks 8 weeks - routine schedule 12 weeks - routine schedule 16 weeks - routine schedule 1 year
