HIV PreP

Question 1

Who is eligible for PreP?

Answer 1

HIV negative at baseline

MSM who are identified as being at elevated risk of HIV acquisition through condomless anal sex

MSM who have a sexual partner who is HIV positive. Unless they are known to have a viral load <200 for 6 months

Heterosexual men/women who are at risk from sexual partner who is HIV positive. Unless they are known to have a viral load <200 for 6 months

PWID - not generally recommended

Question 2

What drugs are used as PreP?

Answer 2

Tenofovir and Emtricitabine
200mg/245mg

once daily

28 days

Question 3

PreP is not recommend for PWID

When might this advice change?

Answer 3

Can be changed on case by case basis

or if there is an outbreak situation or other reasons that put them at risk of HIV acquisition

Question 4

What are common dosage schedules for PreP?

Answer 4

Daily dosing - take for 7 days before having sex

On-demand dosing
2 tablets 24 hours before sex
1 tablet at time of event
1 tablet 24 hour after sex

Question 5

What are common side effects of PreP?

Answer 5

Recipients should be advised of the possibility of transient nausea,
vomiting or headache and encouraged to manage this through the use of simple analgesics and anti-emetics

Question 6

What testing should be performed prior and during PreP?

Answer 6

HIV testing every 3 months
If acute seroconversion suspected - needs a viral load to check is testing results may get complicated

STI screen evert 3 months - chlamydia/ gonorrhoea/ sypihlis

annual renal function check