Mpox Flashcards
1
Q
What is the mechanism of action of tecovirimat?
A
Tecovirimat is an inhibitor of the orthopoxvirus VP37 envelope wrapping protein and is indicated for the treatment of human smallpox disease in adults
VP37 envelope protein is necessary for the production of extracellular virus
2
Q
What type of vaccine is Imvanex?
A
Live attenuated modified Vaccinia virus - Anakara
Replication deficient vaccine
Does not cause rash or disease, as has been passed through cell culture enough that most virulence factors are lost. As opposed to older Smallpox vaccine which can cause disease
