Vaccines Flashcards
antibody is given to protect against infection–produces instant effect
Passive immunization
stimulation of the immune system to produce antigen-specific humoral (antibody) and cellular immunity
active immunization (takes time to develop immunity)
“Wild” virus or bacterium is modified, allowing it to replicate but isn’t active
Live attenuated vaccine (delicate)
safety and efficacy are a _____-______
teeter-taughter
_____ - _________ vaccines always require multiple doses
non-replicating (“prime the pump”)
PPD
purified protein derivative
inactive vaccines are ___ efficacious. Immunity ______ over time –thus we need a ________. Pg 4
Less,
wannes,
booster
protein-based or polysaccharide-based vaccines
Fractional vaccines
a franctional vaccine linked to a protein molecule which changes the immune response from the T-cell independent to T-cell DEPENDENT, leading to increased immunogenicity and allows for a _________ response
Conjugated vaccine,
BOOSTER
3 categories of ADRs to vaccines (3)
- Local (least severe–pain and redness at injection site)
- Systemic (live vaccines) (fever, malaise, headache)
- Allergic anaphylactic (most severe)
Contraindications for LIVE vaccine (6)
- allergy to conponent
- encephalopathy
- pregnancy
- immunosuppression
Contraindications for Inactivated vaccine (2)
- allergy to component
2. encephalopathy
Precaution for LIVE vaccine (2)
- severe illness
2. Recent blood products
INVALID vaccine contraindications (5)
- Mild illness
- antimicrobial therapy
- disease exposure
- pregnancy/ immunosuppressed person in household
- breastfeeding
Most likely to die from Pertussis aka_________ ?
Whooping cough,
secondary infection due to ^ secretions (pneumonia, encephalopathy)
