Living Pharm List

Question 1

Extended-spectrum antibiotic--cell wall synthesis inhibitor--Active against streptococcus
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Answer 1

• Penicillin
• Amoxicillin
• Amoxil
• GI disturbances, hypersensitivity rxn IgM (MORBILLIFORM rash)
• DIs + add aminoglycoside to kill enterococci
  - w/ bacteriostatic antibiotics and oral contraceptives
• Mild to moderate bacterial infections

Question 2

Extended-spectrum antibiotic-- combo: penicillin and Antibeta-lactamas--cell wall/beta-lactamase inhibitor--Active against streptococcus species
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Answer 2

• Amoxicillin w/ Claculante
• Augmentin
• Bacteriostatic antibiotics and oral contraceptives
• Mild to moderat infections w/ beta-lactamase bacteria

Question 3

Analgesic/ antipyretic--selective COX2 inhibitor CENTRALLY--no antiiflammation--excess=liver toxicity 
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Answer 3

• acetaminophen
• tylenol
• N/A
• Fever, Pain

Question 4

Analgesic and Antiinflammatory drug--non-selective COX inhibitor-- antiinflammatory affect takes longer to set in
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Answer 4

• Ibuprofen
• Advil, Motrin
• N/A
• Fever, Pain, Inflammation
• GI, Heart, Kidney

Question 5

Antibiotic--cell wall synthesis inhibitor--actvie against gram+ cocci-- 
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Answer 5

• Cephalosporin
• Cephalaxin
• Keflex
• bacteriostatic antibiotics and oral contraceptives
• mild to moderate bacterial infections
• severe hypersensitivity rxns, secondary infections

Question 6

Antibiotic--bacteriostatic--protein synthesis inhibitor--active against "atypicals", some gram+and- 
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Answer 6

• Marcolide
• Azithromycin
• Zithromax
• N/A
• mild to moderate bacterial infection–PENICILLIN alternative
• hypersensitivity, secondary infections, ^ QT interval

Question 7

Antibiotic kills pathogens through FREE RADICAL FORMATION. Active against ANAEROBIC bacteria and protozoa.
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Answer 7

• Nitroimidazole
• Metronidazole
• Flagyl
• alcohol, warfarin
• Anaerobic bacterial or protozoal infections
• Gi upset, peripheral neuropathy, may be CARCINOGENIC

Question 8

Antiprotozoal that disrupts growth and division of the worm; most active against intestinal worms (drug not absorbed well).
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Answer 8

• Anthelmintic
• Mebendazole
• Vermox
• N/A
• Intestinal Helminth infection
• Allergic rxn possible (pathogen dying release of antigen)

Question 9

Antiviral acts as nucleoside analog halting viral DNA replication. Active against HSV (good) and VZV (moderate)
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Answer 9

• Antiherpetic
• Acyclovir
• Zovirax
• N/A
• Herpetic viral infections
• GI disturbance, nephrotoxicity

Question 10

Antiinflammatory drug that reduces the PRODUCTION and ACTIVITY of inflammatory mediators, i.e. prostaglandins and kinins. May weaken immune system, so beware of active infections (TB). Taper long term steroid, thus closely monitor.
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Answer 10

• Corticosteroid
• Prednisone
• Deltasone
• drugs that ^orv hepatic enzymes, oral anticoagulants
• 1. inflammatory condition 2. immune suppression 3. glucocorticoid replacement therapy
• immune suppression, complicate some chronic diseases, etc.

Question 11

Antifungal that inhibits a CYP450 enzyme, preventing PRODUCTION of ERGOSTEROL (fungecidal). Active against: 1. Candida albicans 2. Cryptococcus neoformans 3. Coccidiodies immitis. Absorbed well, eliminated by kidneys. 
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Answer 11

• Azole
• Fluconazole
• Diflucan
• Many due to CYP450 inhibition
• 1. Candidal infections 2. Cryptococcal meningitis
• decreased steroid production, hepatotoxicity